Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543, Singapore; Waters Pacific Pte. Ltd., 1 Science Park Road, Singapore Science Park II, Singapore 117528, Singapore.
J Pharm Biomed Anal. 2014 Jan;87:130-41. doi: 10.1016/j.jpba.2013.05.036. Epub 2013 May 28.
Recent advances in monolithic columns have made them an alternative to traditional packed columns used in liquid chromatography as well as capillary electrochromatography (CEC). The monolithic columns have been extensively studied and shown to possess several advantages that make them a promising and potential substitute for the particle packed columns. A large number of papers relating to monolithic columns have been published every year, focusing on different preparation techniques, characteristic evaluations as well as applications. This review highlighted the latest development of monoliths for other modes of analytical chemistry. In particular, this review will highlight the application of monoliths for sample preparation which is an important step of the entire analysis.
近年来，整体柱已经成为液相色谱和毛细管电色谱（CEC）中传统填充柱的替代品。整体柱已经得到了广泛的研究，并显示出了一些优势，使其成为颗粒填充柱的一种有前途和潜在的替代品。每年都有大量与整体柱相关的论文发表，重点关注不同的制备技术、特性评估以及应用。本综述重点介绍了整体柱在分析化学其他模式中的最新发展。特别是，本综述将重点介绍整体柱在样品制备中的应用，这是整个分析过程中的重要步骤。
