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用于脊柱疼痛和神经根病的硬膜外类固醇:一项基于证据的叙述性综述。

Epidural steroids for spinal pain and radiculopathy: a narrative, evidence-based review.

作者信息

Wilkinson Indy, Cohen Steven P

机构信息

aWomack Army Medical Center, Fort Bragg, North Carolina bDepartment of Anesthesiology & Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore cUniformed Services University of the Health Sciences, Bethesda, Maryland, USA.

出版信息

Curr Opin Anaesthesiol. 2013 Oct;26(5):562-72. doi: 10.1097/ACO.0b013e3283628e87.

Abstract

PURPOSE OF REVIEW

Epidural steroid injections (ESIs) are the most commonly performed intervention in pain clinics across the USA and worldwide. In light of the growing use of ESIs, a recent spate of highly publicized infectious complications, and increasing emphasis on cost-effectiveness, the utility of ESI has recently come under intense scrutiny. This article provides an evidence-based review of ESIs, including the most up-to-date information on patient selection, comparison of techniques, efficacy, and complications.

RECENT FINDINGS

The data strongly suggest that ESIs can provide short-term relief of radicular symptoms but are less convincing for long-term relief, and mixed regarding cost-effectiveness. Although some assert that transforaminal ESIs are more efficacious than interlaminar ESIs, and that fluoroscopy can improve treatment outcomes, the evidence to support these assertions is limited.

SUMMARY

The cost-effectiveness of ESI is the subject of great debate, and similar to efficacy, the conclusions one draws appear to be influenced by specialty. Because of the wide disparities regarding indications and utilization, it is likely that indiscriminate use is cost-ineffective, but that judicious use in well-selected patients can decrease healthcare utilization. More research is needed to better refine selection criteria for ESI, and to determine which approach, what dose, and how many injections are optimal.

摘要

综述目的

硬膜外类固醇注射(ESIs)是美国及全球疼痛诊所最常进行的干预措施。鉴于ESIs的使用日益增加、近期一系列备受关注的感染并发症以及对成本效益的日益重视,ESI的效用最近受到了严格审查。本文对ESIs进行了基于证据的综述,包括有关患者选择、技术比较、疗效和并发症的最新信息。

最新发现

数据有力地表明,ESIs可以提供神经根症状的短期缓解,但对于长期缓解的说服力较弱,且在成本效益方面存在争议。尽管一些人断言经椎间孔ESIs比椎板间ESIs更有效,且荧光镜检查可改善治疗效果,但支持这些断言的证据有限。

总结

ESI的成本效益是一个备受争议的话题,与疗效类似,得出的结论似乎受专业影响。由于适应症和使用方面存在巨大差异,不加区分地使用可能在成本上无效,但在精心挑选的患者中明智地使用可以降低医疗保健利用率。需要更多研究来更好地完善ESI的选择标准,并确定哪种方法、何种剂量以及注射多少次最为合适。

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