人博卡病毒和肺炎支原体感染中的树突状细胞。

Dendritic cells in human Pneumovirus and Metapneumovirus infections.

机构信息

Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA.

出版信息

Viruses. 2013 Jun 20;5(6):1553-70. doi: 10.3390/v5061553.

DOI:10.3390/v5061553

PMID:23787776

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3717721/

Abstract

Lung dendritic cells (DC) play a fundamental role in sensing invading pathogens, as well as in the control of tolerogenic responses in the respiratory tract. Their strategic localization at the site of pathogen entry makes them particularly susceptible to initial viral invasion. Human respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV) belong to the Paramyxoviridae family, within the Pneumovirus and Metapneumovirus genera, respectively. hRSV and hMPV are significant human respiratory pathogens that cause similar clinical manifestations and affect many of the same subpopulations. However, they differentially activate the host immune response, including DC, which represents a fundamental link between the innate and adaptive immune response. In this review, the role of DC in the immune response against hRSV and hMPV infections, as well as the inhibitory effects of these paramyxoviruses on the DC immunity will be discussed.

摘要

肺树突状细胞（DC）在感知入侵病原体以及控制呼吸道耐受反应方面发挥着重要作用。它们在病原体进入部位的战略定位使它们特别容易受到初始病毒入侵的影响。人类呼吸道合胞病毒（hRSV）和人类偏肺病毒（hMPV）分别属于副黏病毒科的肺病毒属和偏肺病毒属。hRSV 和 hMPV 是重要的人类呼吸道病原体，引起相似的临床症状，并影响许多相同的亚群。然而，它们以不同的方式激活宿主免疫反应，包括 DC，这是先天免疫和适应性免疫反应之间的重要联系。在这篇综述中，将讨论 DC 在 hRSV 和 hMPV 感染免疫反应中的作用，以及这些副黏病毒对 DC 免疫的抑制作用。