Department of Kinesiology and Community Health, University of Illinois, Urbana, IL 61801, USA.
Psychosom Med. 2013 Jul-Aug;75(6):575-80. doi: 10.1097/PSY.0b013e31829b4525. Epub 2013 Jun 20.
To provide a quantitative synthesis of randomized controlled trials examining the effect of exercise training on symptomatic fatigue in persons with multiple sclerosis (MS).
Electronic databases (Web of Science, PubMed, PsycInfo, and Google Scholar) were searched for articles published between 1960 and October 2012 by using the key words "fatigue," OR "tiredness," OR "energy," OR "mood," OR "lassitude," AND "exercise," OR "physical activity," OR "rehabilitation," OR "fitness" WITH "multiple sclerosis." The initial search resulted in 311 articles, of which 74 were reviewed in detail and 17 met the inclusion criteria and provided enough data to compute effect sizes (ESs; Cohen d). The meta-analysis was conducted using a meta-analysis software program, and a random-effects model was used to calculate the overall ES, expressed as Hedge g.
The weighted mean ES from 17 randomized controlled trials with 568 participants with MS was 0.45 (standard error = 0.12, 95% confidence interval = 0.22-0.68, z = 3.88, p ≤ .001). The weighted mean ES was slightly heterogeneous (Q = 29.9, df = 16, p = .019).
The cumulative evidence supports that exercise training is associated with a significant small reduction in fatigue among persons with MS.
对锻炼训练对多发性硬化症患者的症状性疲劳的影响进行随机对照试验的定量综合分析。
通过使用关键词“疲劳”、“疲倦”、“能量”、“情绪”、“乏力”和“锻炼”、“体力活动”、“康复”、“健身”，检索 1960 年至 2012 年 10 月期间发表的电子数据库（Web of Science、PubMed、PsycInfo 和 Google Scholar）中的文章。最初的搜索结果产生了 311 篇文章，其中 74 篇进行了详细审查，17 篇符合纳入标准，并提供了足够的数据来计算效应大小（ES；Cohen d）。使用荟萃分析软件程序进行荟萃分析，使用随机效应模型计算整体 ES，用 Hedge g 表示。
来自 17 项随机对照试验（568 名多发性硬化症患者）的加权平均 ES 为 0.45（标准误差=0.12，95%置信区间=0.22-0.68，z=3.88，p≤.001）。加权平均 ES 存在一定程度的异质性（Q=29.9，df=16，p=0.019）。
累积证据支持锻炼训练与多发性硬化症患者的疲劳显著减少相关。
