Tas P W, Kress H G, Koschel K
Institute for Virology and Immunology, University of Würzburg, F.R.G.
Biochim Biophys Acta. 1990 Jul 9;1026(1):40-2. doi: 10.1016/0005-2736(90)90329-m.
Lack of selectivity towards anesthetic stereoisomers is one of the few criteria available for the identification of an anesthetic target site. Until now this criterion has not been tested for anesthetics that directly interact with sensitive membrane proteins which are considered the targets of anesthetic action. In this communication we show that stereoisomers of 2-butanol and 2,4-pentanediol did not differ in their inhibitory potency for a site located on the Na+/K+/Cl- co-transporter protein. This suggests that an inhibition site on a membrane protein can fulfill the criterion of lack of stereoisomer selectivity.
对麻醉剂立体异构体缺乏选择性是可用于识别麻醉靶点的少数标准之一。到目前为止，尚未针对与被认为是麻醉作用靶点的敏感膜蛋白直接相互作用的麻醉剂测试该标准。在本通讯中，我们表明2-丁醇和2,4-戊二醇的立体异构体对位于Na+/K+/Cl-共转运蛋白上的位点的抑制效力没有差异。这表明膜蛋白上的抑制位点可以满足缺乏立体异构体选择性的标准。
