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HCCS1在非小细胞肺癌中的表达及临床意义

Expression and clinical significance of HCCS1 in non-small cell lung cancer.

作者信息

Xiao-Yong Shen, Zhi-Feng Lin, Fan-Zhen Lu, Zhen Ruan, Jian Zhen, Hai-Long Huang, Chao-Qiang Ju

机构信息

Department of Thoracic Surgery, The Huadong Hospital, Shanghai Fudan University, Shanghai, China ; Lin Zhi-Feng and Shen Xiao-Yong should be regarded as co-first authors.

出版信息

Contemp Oncol (Pozn). 2012;16(4):328-31. doi: 10.5114/wo.2012.30062. Epub 2012 Sep 29.

DOI:10.5114/wo.2012.30062
PMID:23788903
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3687437/
Abstract

AIM OF THE STUDY

Hepatocellular carcinoma suppressor 1 (HCCS1) has been identified as a tumor suppressor gene in the high-frequency loss of heterozygosity (LOH) region on chromosome 17p13.3 in hepatocellular carcinoma (HCC). There was also a high frequency of LOH on chromosome 17p13.3 in non-small cell lung cancer (NSCLC). Therefore, the aim of this study was to explore the expression of HCCS1 in NSCLC as well as its clinical significance.

MATERIAL AND METHODS

Real-time PCR and immunohistochemistry were performed to detect the expression level of HCCS1 mRNA and protein in NSCLC and noncancerous tissues, respectively. Further, we explored the relationship between HCCS1 expression and various clinical features in NSCLC.

RESULTS

The mRNA and protein expression of HCCS1 were both significantly lower in NSCLC samples than those in noncancerous tissues. That is, the mRNA level of HCCS1 was 0.0044 ±0.0036 and 0.0067 ±0.0054 in NSCLC samples and noncancerous tissues, respectively. The protein level of HCCS1 was 4.67 ±1.15 and 6.13 ±1.24 in NSCLC samples and noncancerous tissues, respectively. Importantly, this difference in expression was significantly correlated with tumor lymph node metastasis (TNM) in NSCLC (p < 0.05), but not with gender and age of the patients, pathological types, TNM stages, or grades of cancers (p > 0.05).

CONCLUSION

Our results suggest that HCCS1 may be involved in NSCLC carcinogenesis.

摘要

研究目的

肝细胞癌抑制因子1（HCCS1）已被确定为肝细胞癌（HCC）中17p13.3染色体高频杂合性缺失（LOH）区域的一个抑癌基因。在非小细胞肺癌（NSCLC）中，17p13.3染色体上也存在高频LOH。因此，本研究的目的是探讨HCCS1在NSCLC中的表达及其临床意义。

材料与方法

分别采用实时荧光定量PCR和免疫组织化学方法检测NSCLC组织和癌旁组织中HCCS1 mRNA和蛋白的表达水平。此外，我们还探讨了NSCLC中HCCS1表达与各种临床特征之间的关系。

结果

NSCLC样本中HCCS1的mRNA和蛋白表达均显著低于癌旁组织。也就是说，NSCLC样本和癌旁组织中HCCS1的mRNA水平分别为0.0044±0.0036和0.0067±0.0054。NSCLC样本和癌旁组织中HCCS1的蛋白水平分别为4.67±1.15和6.13±1.24。重要的是，这种表达差异与NSCLC中的肿瘤淋巴结转移（TNM）显著相关（p<0.05），但与患者的性别、年龄、病理类型、TNM分期或癌症分级无关（p>0.05）。

结论

我们的结果表明，HCCS1可能参与了NSCLC的发生发展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/969b/3687437/d919d79fac53/WO-16-19110-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/969b/3687437/d919d79fac53/WO-16-19110-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/969b/3687437/d919d79fac53/WO-16-19110-g001.jpg

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本文引用的文献

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Adenovirus-mediated HCCS1 overexpression elicits a potent antitumor efficacy on human colorectal cancer and hepatoma cells both in vitro and in vivo.腺病毒介导的HCCS1过表达在体外和体内均对人结肠癌细胞和肝癌细胞产生强大的抗肿瘤功效。
Cancer Gene Ther. 2008 Dec;15(12):808-16. doi: 10.1038/cgt.2008.52. Epub 2008 Jul 11.
2
HCCS1 overexpression induces apoptosis via cathepsin D and intracellular calcium, and HCCS1 disruption in mice causes placental abnormality.HCCS1过表达通过组织蛋白酶D和细胞内钙诱导细胞凋亡，并且小鼠中HCCS1功能破坏会导致胎盘异常。
Cell Death Differ. 2008 Sep;15(9):1481-90. doi: 10.1038/cdd.2008.73. Epub 2008 May 30.
3
The tail-anchoring domain of Bfl1 and HCCS1 targets mitochondrial membrane permeability to induce apoptosis.
Bfl1和HCCS1的尾锚定结构域靶向线粒体膜通透性以诱导细胞凋亡。
J Cell Sci. 2007 Aug 15;120(Pt 16):2912-23. doi: 10.1242/jcs.006197. Epub 2007 Jul 31.
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Genetic alterations of the HCCS1 gene in Korean hepatocellular carcinoma.韩国肝细胞癌中HCCS1基因的遗传改变
APMIS. 2003 Apr;111(4):465-73. doi: 10.1034/j.1600-0463.2003.1110403.x.
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Detailed characterization of a homozygously deleted region corresponding to a candidate tumor suppressor locus at distal 17p13.3 in human lung cancer.对人肺癌17号染色体短臂13.3远端一个与候选肿瘤抑制基因座相对应的纯合缺失区域的详细特征分析。
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