Kołodziejczyk Joanna, Ponczek Michał B
Department of General Biochemisrty, University of Lodz, Lodz, Poland.
Contemp Oncol (Pozn). 2013;17(2):113-9. doi: 10.5114/wo.2013.34611. Epub 2013 Apr 29.
Participation of fibrin, fibrinogen, and their degradation products in pathogenesis and progression of cancer may lead to complications of thromboembolic events. The tumor may be a source of fibrinogen. Fibrinogen inside the tumor is one of the factors of its growth and metastasis. Fibrinogen, fibrin and their degradation products possess proinflammatory activity. They indirectly stimulate endothelium to secrete von Willebrand factor, leading to activation of platelets accompanying neoplastic disorders. Fragments E and D are the end products of fibrin(ogen) degradation and E and DD are the end products of stabilized fibrin. E stimulates proliferation, migration and differentiation of endothelial cells, contributing to tumor vasculature. Increased levels of DD are observed in malignant neoplasms, such as breast, lung, colon and ovary cancers. In breast cancers DD correlates with progression of disease and metastasis. The role of fibrinogen and the products of its degradation in the progression of various tumors is not sufficiently understood.
纤维蛋白、纤维蛋白原及其降解产物参与癌症的发病机制和进展，可能导致血栓栓塞事件并发症。肿瘤可能是纤维蛋白原的来源。肿瘤内的纤维蛋白原是其生长和转移的因素之一。纤维蛋白原、纤维蛋白及其降解产物具有促炎活性。它们间接刺激内皮细胞分泌血管性血友病因子，导致伴随肿瘤性疾病的血小板活化。E片段和D片段是纤维蛋白（原）降解的终产物，E片段和DD片段是稳定纤维蛋白的终产物。E片段刺激内皮细胞的增殖、迁移和分化，有助于肿瘤血管生成。在恶性肿瘤如乳腺癌、肺癌、结肠癌和卵巢癌中观察到DD水平升高。在乳腺癌中，DD与疾病进展和转移相关。纤维蛋白原及其降解产物在各种肿瘤进展中的作用尚未得到充分了解。
