Janiszewska Anna Daria, Poletajew Sławomir, Wasiutyński Aleksander
Department of Pathology, Medical University of Warsaw, Warsaw, Poland.
Contemp Oncol (Pozn). 2013;17(2):123-7. doi: 10.5114/wo.2013.34613. Epub 2013 Apr 29.
Renal cell carcinoma (RCC) comprises 3-4% of all malignant tumours among adults in Poland. Spontaneous regression of RCC is a rare but well-known phenomenon. Its frequency is estimated to be approximately 1% and a large part of the percentage is accounted for by the regression of pulmonary metastases in the course of clear type of RCC treatment. We searched PubMed, Embase and SciVerse Scopus databases, identifying 59 case reports of spontaneous regression of RCC. Those medical histories come from reports from around the world and date back up to 40 years. This review includes their analysis as well as description of possible explanations of this phenomenon postulated by different authors, including both misdiagnosis and immunological reactions. This study indicates that reliable diagnostics and reporting of all the cases of spontaneous regression play a key role, as this is the only method which enables a better perspective in understanding this issue.
在波兰，肾细胞癌（RCC）占成人所有恶性肿瘤的3%-4%。RCC的自发消退是一种罕见但广为人知的现象。其发生率估计约为1%，其中很大一部分是在透明型RCC治疗过程中肺转移灶的消退。我们检索了PubMed、Embase和SciVerse Scopus数据库，确定了59例RCC自发消退的病例报告。这些病史来自世界各地的报告，时间可追溯到40年前。本综述包括对它们的分析以及对不同作者提出的这一现象可能解释的描述，包括误诊和免疫反应。本研究表明，对所有自发消退病例进行可靠的诊断和报告起着关键作用，因为这是能够更好地理解这一问题的唯一方法。
