Program in Neurosciences & Mental Health, Hospital for Sick Children; Department of Psychology; Department of Physiology; Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada.
Genes Brain Behav. 2014 Jan;13(1):118-25. doi: 10.1111/gbb.12058. Epub 2013 Jul 12.
In the brain, transcription factors are critical for linking external stimuli to protein production, enabling neurons and neuronal networks to adapt to the ever-changing landscape. Gene transcription and protein synthesis are also vital for the formation of long-term memory. Members of the myocyte enhancer factor-2 (MEF2) family of transcription factors have a well-characterized role in the development of a variety of tissues, but their role in the adult brain is only beginning to be understood. Recent evidence indicates that MEF2 regulates the structural and synaptic plasticity underlying memory formation. However, in stark contrast to most other transcription factors implicated in memory, MEF2-mediated transcription constrains (rather than promotes) memory formation. Here, we review recent data examining the role of MEF2 in adult memory formation in rodents.
在大脑中，转录因子对于将外部刺激与蛋白质产生联系至关重要，使神经元和神经网络能够适应不断变化的环境。基因转录和蛋白质合成对于形成长期记忆也至关重要。肌细胞增强因子 2（MEF2）转录因子家族的成员在多种组织的发育中具有明确的作用，但它们在成年大脑中的作用才刚刚开始被理解。最近的证据表明，MEF2 调节记忆形成的结构和突触可塑性。然而，与大多数其他参与记忆的转录因子形成鲜明对比的是，MEF2 介导的转录限制（而不是促进）记忆形成。在这里，我们回顾了最近的数据，这些数据检查了 MEF2 在啮齿动物成年记忆形成中的作用。
