Lete Iñaki, Cuesta María C, Marín Juan M, Guerra Sandra
Department of Gynaecology, Hospital Universitario Araba-Santiago, Basque Health Service-Osakidetza, Vitoria, Spain.
Eur J Contracept Reprod Health Care. 2013 Aug;18(4):234-41. doi: 10.3109/13625187.2013.801954. Epub 2013 Jun 24.
To provide an overview of the available data from clinical studies of vaginal conditions in women who use a vaginal ring as a contraceptive.
A systematic review of the literature.
Millions of women have already used the ethylene vinyl acetate vaginal ring that releases ethinylestradiol and etonogestrel for contraception. Because of its small size, more than four out of five women using the ring report that they do not feel it, even during sexual intercourse. No colposcopic or cytological changes have been observed in users, although approximately 10% have increased vaginal discharge. While in vitro studies have shown adhesion of Candida yeasts to the vaginal ring surface, clinical studies have not demonstrated a greater incidence of Candida infections compared to users of equivalent oral contraceptives. Some clinical studies suggest a lower incidence of bacterial vaginosis. No interaction exists between concomitant use of the vaginal ring and other drugs or products for vaginal use.
The use of a contraceptive vaginal ring does not alter the vaginal ecosystem and therefore does not substantially affect vaginal health.
概述使用阴道环作为避孕方法的女性阴道状况临床研究的现有数据。
对文献进行系统综述。
数以百万计的女性已经使用了释放炔雌醇和依托孕烯的乙烯-醋酸乙烯酯阴道环进行避孕。由于其尺寸小,超过五分之四使用该阴道环的女性报告称,即使在性交期间也感觉不到它的存在。虽然在使用者中未观察到阴道镜或细胞学变化,但约10%的使用者白带增多。虽然体外研究表明念珠菌酵母可附着在阴道环表面,但临床研究并未证明与使用同等口服避孕药的使用者相比,念珠菌感染的发生率更高。一些临床研究表明细菌性阴道病的发生率较低。同时使用阴道环与其他阴道用药或产品之间不存在相互作用。
使用避孕阴道环不会改变阴道生态系统,因此不会对阴道健康产生实质性影响。