Department of Obstetrics and Gynaecology, University of Auckland, Auckland, New Zealand; Department of Physiology, University of Auckland, Auckland, New Zealand.
Am J Reprod Immunol. 2013 Nov;70(5):412-27. doi: 10.1111/aji.12138. Epub 2013 Jun 24.
Published reports testing the association between cytokine levels and preeclampsia are conflicting. This comprehensive systematic review and meta-analysis aimed at testing the association between preeclampsia and maternal circulating tumor necrosis factor-alpha (TNF-α), interleukin (IL)-6, and IL-10.
A systematic literature search of studies reporting maternal circulating TNF-α, IL-6, and IL-10 in women with preeclampsia and normotensive pregnant women was conducted yielding 41, 28, and 12 eligible reports, respectively.
Both mild preeclampsia and severe preeclampsia were associated with elevated TNF-α [mean difference (MD) = 7.34 pg/mL, 95% CI 5.02-9.66 and MD = 7.91 pg/mL, 95% CI 4.72-11.10, respectively] and IL-6 (MD = 61.01 pg/mL, 95% CI 14.24-107.77 and MD = 28.54 pg/mL, 95% CI 15.90-41.17, respectively) in the third trimester. Preeclampsia was also associated with elevated levels of IL-10 (MD = 5.54, 95% CI 0.69-10.38). The systematic review of studies reporting median data was in consensus with the parametric data.
This systematic review and meta-analysis with accompanying summary of non-parametric data shows elevated maternal circulating TNF-α, IL-6, and IL-10 levels in preeclampsia.
已发表的报告检测细胞因子水平与子痫前期之间的关系存在冲突。本项全面的系统评价和荟萃分析旨在检测子痫前期与母体循环肿瘤坏死因子-α（TNF-α）、白细胞介素（IL）-6 和 IL-10 之间的关系。
系统地检索了报道子痫前期和正常孕妇母体循环 TNF-α、IL-6 和 IL-10 的研究报告，分别产生了 41、28 和 12 份合格报告。
轻度子痫前期和重度子痫前期均与 TNF-α 升高相关[平均差异（MD）=7.34 pg/mL，95%置信区间（CI）5.02-9.66 和 MD = 7.91 pg/mL，95%CI 4.72-11.10]，且在孕晚期 IL-6 升高[MD = 61.01 pg/mL，95%CI 14.24-107.77 和 MD = 28.54 pg/mL，95%CI 15.90-41.17]。子痫前期也与 IL-10 水平升高相关（MD = 5.54，95%CI 0.69-10.38）。报告中位数数据的研究系统评价与参数数据一致。
本项系统评价和荟萃分析，以及伴随的非参数数据综述表明，子痫前期母体循环 TNF-α、IL-6 和 IL-10 水平升高。
