激酶DFG模体的来龙去脉
Ins and outs of kinase DFG motifs.
作者信息
Treiber Daniel K, Shah Neil P
机构信息
KINOMEscan Division of DiscoveRx Corporation, 11180 Roselle Street, Suite D, San Diego, CA, 92121, USA.
出版信息
Chem Biol. 2013 Jun 20;20(6):745-6. doi: 10.1016/j.chembiol.2013.06.001.
Abstract
In this issue of Chemistry & Biology, Hari and colleagues show that two positions in kinase active sites, including the well-known "gatekeeper" residue, regulate "in" versus "out" conformations of the conserved "DFG" motif. These findings suggest yet another role for the gatekeeper residue.
摘要
在本期《化学与生物学》中，哈里及其同事表明，激酶活性位点中的两个位置，包括著名的“守门人”残基，调节保守的“DFG”基序的“向内”与“向外”构象。这些发现表明了守门人残基的另一个作用。
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