Korean BioInformation Center (KOBIC), KRIBB, Daejeon 305-333, Korea.
BMB Rep. 2013 Jun;46(6):305-9. doi: 10.5483/bmbrep.2013.46.6.177.
The determination of relatedness between individuals in a family is crucial in analysis of common complex diseases. We present a method to infer close inter-familial relationships based on SNP genotyping data and provide the relationship coefficient of kinship in Korean families. We obtained blood samples from 43 Korean individuals in two families. SNP data was obtained using the Affymetrix Genome-wide Human SNP array 6.0 and the Illumina Human 1M-Duo chip. To measure the kinship coefficient with the SNP genotyping data, we considered all possible pairs of individuals in each family. The genetic distance between two individuals in a pair was determined using the allele sharing distance method. The results show that genetic distance is proportional to the kinship coefficient and that a close degree of kinship can be confirmed with SNP genotyping data. This study represents the first attempt to identify the genetic distance between very closely related individuals.
在分析常见的复杂疾病时，确定家族成员之间的亲缘关系至关重要。我们提出了一种基于 SNP 基因分型数据推断近亲关系的方法，并提供了韩国家族的亲缘关系系数。我们从两个家庭的 43 名韩国个体中获得了血液样本。SNP 数据使用 Affymetrix Genome-wide Human SNP Array 6.0 和 Illumina Human 1M-Duo 芯片获得。为了用 SNP 基因分型数据测量亲缘系数，我们考虑了每个家庭中所有可能的个体对。通过等位基因共享距离法确定个体对中两个个体之间的遗传距离。结果表明，遗传距离与亲缘系数成正比，并且可以通过 SNP 基因分型数据确认密切的亲缘关系。这项研究代表了首次尝试确定非常近亲个体之间的遗传距离。
