Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA.
Psychiatry Res. 2013 Aug 15;208(3):225-31. doi: 10.1016/j.psychres.2013.05.024. Epub 2013 Jun 19.
We investigated prospectively documented parental age and bipolar disorder (BD) in a multi-ethnic birth cohort. The study was based on a nested case-control design from the Child Health and Development Study (CHDS) birth cohort from 1959 to 1966. Potential cases with BD were ascertained by database linkages between CHDS, Kaiser Permanente Medical Care Plan (KPNC), and Alameda County Behavioral Health Care Services, and mailed questionnaires. Consensus diagnoses with the SCID for DSM-IV-TR were made. The total number of BD cases was 94. Controls (N=746) were selected from the birth cohort and matched on date of birth, sex, and KPNC membership or residence in Alameda County. For every 10-year increment of paternal age, there was no significant association with BD, adjusting for maternal age. There was also no significant association between maternal age, modeled in 10-year increments, and risk of BD after adjustment for paternal age and maternal race, although there was a suggestion for a protective relationship between increasing maternal age and BD with psychotic features. These findings suggest that if advanced paternal age is a risk factor for BD, the strength of the relationship is small.
我们前瞻性地研究了多民族出生队列中父母年龄与双相情感障碍（BD）的关系。该研究基于 1959 年至 1966 年的儿童健康与发展研究（CHDS）出生队列中的嵌套病例对照设计。通过 CHDS、Kaiser Permanente 医疗保健计划（KPNC）和阿拉米达县行为保健服务之间的数据库链接以及邮寄问卷来确定潜在的 BD 病例。使用 DSM-IV-TR 的 SCID 进行共识诊断。BD 总病例数为 94 例。对照组（N=746）选自出生队列，并根据出生日期、性别以及 KPNC 会员资格或在阿拉米达县的居住情况进行匹配。在调整了母亲年龄后，父亲年龄每增加 10 年，与 BD 无显著关联。在调整了父亲年龄和母亲种族后，母亲年龄每增加 10 年，与 BD 的风险也没有显著关联，但有迹象表明，母亲年龄的增加与伴有精神病特征的 BD 之间存在保护关系。这些发现表明，如果父亲年龄较大是 BD 的一个危险因素，那么这种关系的强度很小。
