Department of Criminology and Criminal Justice, Western Carolina University, Cullowhee, NC 28723, United States.
Psychiatry Res. 2013 Nov 30;210(1):247-55. doi: 10.1016/j.psychres.2013.04.022. Epub 2013 Jun 18.
The current study used a variable- and person-centered approach to examine whether a DRD4 polymorphism explained within-individual differences in frequency of marijuana use from adolescence into emerging adulthood. Data were analyzed from 1897 respondents from the genetic subsample of the National Longitudinal Study of Adolescent Health (Add Health) at waves I (ages 13-17), II (ages 14-18), and III (ages 21-25). Latent class growth model results revealed that marijuana use was characterized by four trajectories (non-users/experimenters, increasers, desisters, and chronic users), and that the DRD4 polymorphism differentiated increasers from non-users/experimenters. Overall, the results suggested that the DRD4 polymorphism may be relevant to differences in the developmental trajectories of marijuana use.
本研究采用变量和个体中心的方法，检验 DRD4 多态性是否可以解释从青少年到成年早期的大麻使用频率的个体内差异。数据来自国家青少年健康纵向研究（Add Health）的遗传子样本中的 1897 名受访者，分别在第 I 波（年龄 13-17 岁）、第 II 波（年龄 14-18 岁）和第 III 波（年龄 21-25 岁）进行了分析。潜在类别增长模型的结果表明，大麻使用有四个轨迹（非使用者/实验者、增加者、减少者和慢性使用者），DRD4 多态性将增加者与非使用者/实验者区分开来。总体而言，研究结果表明，DRD4 多态性可能与大麻使用的发展轨迹差异有关。
