Department of Physiology, Dokuz Eylul University, Turkey.
Neurosci Lett. 2013 Aug 9;549:177-81. doi: 10.1016/j.neulet.2013.06.012. Epub 2013 Jun 18.
It is already known that regular aerobic exercise during adolescent period improves learning and memory in rats. In this study, we investigated the effects of regular aerobic exercise on learning, memory functioning and IGF-1 levels. IGF-1 is known to have positive effects on cognitive functions in adolescent rats. Exercise group was separated into two different groups. First half was run on a treadmill for 30 min per session at a speed of 8m/min and 0° slope, five times a week for 6 weeks. The second half was given free access to a running wheel (diameter 11.5 cm) which was connected to a digital counter and run on a treadmill for 6 weeks. Learning and memory functioning were found to be positively correlated with the exercise activity. Findings suggest increased neuron density in CA1 hippocampal region and dentate gyrus. Increased IGF-1 level was detected in hippocampus and blood serum, while IGF-1 level in liver tissue did not change with exercise activity. In conclusion, our findings indicate that learning and memory functioning were positively affected by voluntary and involuntary physical exercise which correlated increased hippocampal activity and elevated IGF-1 levels in adolescent rats.
已经知道，青少年时期定期进行有氧运动可以改善大鼠的学习和记忆能力。在这项研究中，我们研究了定期有氧运动对学习、记忆功能和 IGF-1 水平的影响。IGF-1 已知对青少年大鼠的认知功能有积极影响。运动组分为两个不同的组。前半部分在跑步机上以 8m/min 和 0°坡度的速度进行，每次 30 分钟，每周 5 次，持续 6 周。后半部分可以自由使用与数字计数器相连的直径为 11.5 厘米的跑步轮，在跑步机上跑步 6 周。学习和记忆功能与运动活动呈正相关。研究结果表明，CA1 海马区和齿状回的神经元密度增加。在海马体和血清中检测到 IGF-1 水平升高，而肝组织中的 IGF-1 水平不受运动活动的影响。总之，我们的研究结果表明，学习和记忆功能受到自愿和非自愿体育锻炼的积极影响，这与青少年大鼠中海马体活性的增加和 IGF-1 水平的升高有关。
