dl-灰黄霉素及其同系物的合成与抗真菌活性。I.

Syntheses and antifungal activities of dl-griseofulvin and its congeners. I.

作者信息

Tomozane H, Takeuchi Y, Choshi T, Kishida S, Yamato M

机构信息

Faculty of Pharmaceutical Sciences, Okayama University, Japan.

出版信息

Chem Pharm Bull (Tokyo). 1990 Apr;38(4):925-9. doi: 10.1248/cpb.38.925.

DOI:10.1248/cpb.38.925

PMID:2379285

Abstract

dl-Griseofulvin (1a) was prepared by two synthetic pathways. New 6'-congeners (3 and 4) of griseofulvin were also prepared. Their antifungal activities were evaluated and compounds 3 and 4 were found to be less active than 1a. Molecular calculations on 1a, dl-epigriseofulvin (1b), 3 and 4 were undertaken.

摘要

通过两条合成途径制备了消旋灰黄霉素（1a）。还制备了灰黄霉素的新型6'-同系物（3和4）。评估了它们的抗真菌活性，发现化合物3和4的活性低于1a。对1a、消旋表灰黄霉素（1b）、3和4进行了分子计算。