Kumana C R, Chan M M, Wong K L, Wong R W, Kou M, Lauder I J
Department of Medicine, University of Hong Kong.
Clin Pharmacol Ther. 1990 Aug;48(2):208-13. doi: 10.1038/clpt.1990.137.
The Chinese in Southeast Asia are recognized as a population group that has a relatively high prevalence of rapid "acetylators" and a relatively high incidence of systemic lupus erythematosus. This study was designed to evaluate the possibility that there were environmental lupus erythematosus provocative substances eliminated by acetylation that resulted in a preponderance of slow acetylators among patients with the disease. We compared acetylator status in 36 Chinese women with mild, stable, and confirmed lupus erythematosus and 36 healthy control subjects matched for age, sex, and ethnic origin. Acetylator status was determined by use of HPLC to assay 5-acetylamino-6-formylamino-3-methyluracil/methylxanthine (AFMU/MX) and AFMU/(AFMU + MX) ratios in urine 1 to 4 hours after drinking a strong cup of coffee (caffeine). By use of parametric and nonparametric methods of analysis, the frequency distribution of AFMU/MX and AFMU/(AFMU + MX) ratios in both the patients and control subjects were determined to be very similar. Thus there was no association between slow acetylator status and lupus erythematosus in the study subjects.
东南亚的华人被认为是快速“乙酰化者”患病率相对较高且系统性红斑狼疮发病率相对较高的人群。本研究旨在评估是否存在通过乙酰化作用被消除的环境性红斑狼疮诱发物质，从而导致该病患者中慢乙酰化者占多数。我们比较了36名患有轻度、稳定且确诊的红斑狼疮的中国女性以及36名年龄、性别和种族匹配的健康对照者的乙酰化状态。乙酰化状态通过在饮用一杯浓咖啡（咖啡因）后1至4小时采集尿液，使用高效液相色谱法测定尿中5-乙酰氨基-6-甲酰氨基-3-甲基尿嘧啶/甲基黄嘌呤（AFMU/MX）和AFMU/（AFMU + MX）比值来确定。通过参数分析和非参数分析方法，确定患者和对照者中AFMU/MX和AFMU/（AFMU + MX）比值的频率分布非常相似。因此，在研究对象中，慢乙酰化状态与红斑狼疮之间没有关联。
