Kose Dogan, Karabagli Pinar, Yavas Güler, Karabagli Hakan, Koksal Yavuz
Faculty of Medicine, Department of Pediatric Hematology and Oncology, Selcuk University, Konya, Turkey,
Childs Nerv Syst. 2013 Oct;29(10):1799-802. doi: 10.1007/s00381-013-2203-8. Epub 2013 Jun 21.
Neuroblastoma (NB) is the most common extracranial solid malignancy in children. The major cause of death from this cancer is metastasis of tumors, and metastasis can be seen in different areas of the body. Metastasis of NB occurs by hematogenous and lymphatic routes. Generally, brain metastases have been reported in only one area of the brain parenchyma.
A 4-year-old male patient was treated in our clinic due to the NB that settled in the intra-abdominal region, but the patient presented with headache and nausea approximately 5 months after completion of the treatment. Whereupon, cranial imaging was performed and two masses were detected in the bilateral frontal lobe, and then the patient underwent surgery. Metastatic NB diagnosis was confirmed histopathologically. The patient's chemotherapy treatment is still ongoing.
We report the case of a male patient with two separate metastatic masses in the brain parenchyma, which occurred in two different areas at the same time.
神经母细胞瘤(NB)是儿童最常见的颅外实体恶性肿瘤。该癌症的主要死因是肿瘤转移,且转移可见于身体的不同部位。NB通过血行和淋巴途径发生转移。一般来说,脑转移仅报道于脑实质的一个区域。
一名4岁男性患者因腹腔内的NB在我们诊所接受治疗,但患者在治疗结束后约5个月出现头痛和恶心。于是,进行了头颅影像学检查,在双侧额叶发现两个肿块,随后患者接受了手术。经组织病理学证实为转移性NB诊断。患者的化疗仍在进行中。
我们报告了一例男性患者,其脑实质内同时在两个不同区域出现两个独立的转移瘤。