Department of Oral Medicine, School of Dental Medicine, University of Zagreb, Zagreb, Croatia.
Wien Klin Wochenschr. 2013 Jul;125(13-14):408-11. doi: 10.1007/s00508-013-0382-7. Epub 2013 Jun 21.
Drug-induced lesions of oral mucosa are well-established side effect of different commonly used drugs. A female patient under treatment for hypertension with an angiotensin-converting enzyme inhibitor (ACE inhibitor), lisinopril, developed blisters and ulcerations on oral mucosa 3 weeks after lisinopril intake. Due to clinical finding drug-induced pemphigus was considered. However, direct and indirect immunofluorescence anal-ysis revealed no autoantibodies that are commonly present in pemphigus while histological study suggested allergic reaction. Lisinopril was discontinued from further therapy and after a month after her first arrival patient has experienced complete remission of the disease. This case raises the question, whether the term pemphigus in drug-induced reactions could be used when immunopathological criteria for pemphigus are not fulfilled.
药物引起的口腔黏膜损伤是多种常用药物的已知副作用。一位女性高血压患者接受血管紧张素转换酶抑制剂（ACEI）赖诺普利治疗，在服用赖诺普利 3 周后口腔黏膜出现水疱和溃疡。由于临床发现，考虑为药物诱导性天疱疮。然而，直接和间接免疫荧光分析未显示天疱疮中常见的自身抗体，而组织学研究提示过敏反应。赖诺普利被停用，一个月后患者的疾病完全缓解。该病例提出了一个问题，即在未满足天疱疮的免疫病理标准时，是否可以在药物诱导反应中使用天疱疮这一术语。
