De Wachter Stefan G G, Heeringa Rhea, Van Koeveringe Gommert A, Winkens Bjorn, Van Kerrebroeck Philip E V, Gillespie James I
Department of Urology, Maastricht University Medical Centre, Maastricht, The Netherlands; Department of Urology, University Antwerpen, Universiteitsplein 1, Wilrijk, Belgium.
Neurourol Urodyn. 2014 Jun;33(5):502-6. doi: 10.1002/nau.22440. Epub 2013 Jun 21.
To present and describe a non-invasive method to study the origin and development of bladder filling sensation and to evaluate the repeatability of the method.
Eighteen volunteers participated in the study and were given a water loading protocol consisting of 1,000 ml water intake 1 hr before the session and 200 ml every 10 min during the session. Protocol 1: To evaluate diuresis rate, seven participants were asked to void every 15 min and the voided volume was measured. Protocol 2: Eleven volunteers graded bladder sensation on regular time points, on an empty graph with time on the X-axis and intensity of sensation on the Y-axis. The protocol ended at absolute need to void (maximal intensity) and voided volumes were measured. This protocol was conducted three times with a 10 days interval.
Protocol 1: The diuresis rate was not different during the sessions and showed no variation over the studied time period (P = 0.2). Protocol 2: For an individual, the diuresis rate was not different between the sessions. The curves in all patients showed a continuously increasing bladder intensity. In seven participants the curve was convex, in the other four, the curve was sigmoidal. For each individual the pattern was constant during the three sessions.
A strict water loading protocol induces a constant diuresis. This allows individuals to draw an introspection bladder sensation curve with a specific shape, which can be used as a method to study the development of bladder sensation non-invasively.
介绍并描述一种用于研究膀胱充盈感觉的起源和发展的非侵入性方法，并评估该方法的可重复性。
18名志愿者参与了该研究，并接受了饮水方案，即在实验前1小时摄入1000毫升水，实验期间每10分钟摄入200毫升水。方案1：为评估利尿速率，7名参与者被要求每15分钟排尿一次，并测量排尿量。方案2：11名志愿者在规定时间点对膀胱感觉进行评分，在一个以时间为X轴、感觉强度为Y轴的空白图表上进行。该方案在绝对需要排尿（最大强度）时结束，并测量排尿量。此方案每隔10天进行三次。
方案1：各实验期间的利尿速率无差异，在研究时间段内也无变化（P = 0.2）。方案2：对于个体而言，各实验期间的利尿速率无差异。所有患者的曲线均显示膀胱强度持续增加。7名参与者的曲线为凸形，另外4名参与者的曲线为S形。对于每个个体，三次实验期间的模式是恒定的。
严格的饮水方案可诱导恒定的利尿。这使得个体能够绘制出具有特定形状的内省膀胱感觉曲线，可作为一种非侵入性研究膀胱感觉发展的方法。
