[四甲基秋兰姆二硫化物和N-亚硝基二乙胺给药后大鼠肝细胞中异种有机抗原——肾脏来源的非组蛋白染色体蛋白的表达]

[Expression of hetero-organic antigens--nonhistone chromosomal proteins of renal nature in liver cells of rats after administration of tetramethylthiuram disulfide and N-nitrosodiethylamine].

作者信息

Klimova A A

出版信息

Eksp Onkol. 1990;12(4):76-7.

Abstract

Tetramethylthiuramdisulfide (TMTD) decreasing the formation of hepatomas in inbred rats with the subsequent intraperitoneal administration of nitrosodiethylamine (NDEA) is established not to affect the NDEA-induced expression of the heteroorganic antigens of nonhistone chromosomal proteins of the kidney nature associated with the hepatoma and regenerating liver cells of rats. It is supposed that changes in the NDEA metabolism induced by the preceeding action of TMTD, obviously, do not influence the hepatocarcinogenic potencies relative to stimulation of cell proliferation.

摘要

已证实，在近交系大鼠腹腔注射亚硝基二乙胺（NDEA）后，四甲基秋兰姆二硫化物（TMTD）减少肝癌形成，但不影响NDEA诱导的与大鼠肝癌和再生肝细胞相关的肾源性非组蛋白染色体蛋白杂有机抗原的表达。据推测，TMTD先前作用诱导的NDEA代谢变化显然不会影响相对于细胞增殖刺激的肝癌致癌潜能。

相似文献

1

[Expression of hetero-organic antigens--nonhistone chromosomal proteins of renal nature in liver cells of rats after administration of tetramethylthiuram disulfide and N-nitrosodiethylamine].[四甲基秋兰姆二硫化物和N-亚硝基二乙胺给药后大鼠肝细胞中异种有机抗原——肾脏来源的非组蛋白染色体蛋白的表达]

Eksp Onkol. 1990;12(4):76-7.

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