[非组蛋白染色体蛋白制剂对原代大鼠肝细胞培养中肾脏来源的异种有机膜抗原表达的影响]

[The effect of preparations of non-histone chromosomal proteins on the expression of hetero-organic membrane antigens of kidney origin in a primary rat hepatocyte culture].

作者信息

Ivanov V A, Fedorov L Iu, Grandilevskaia A B, Klimova A A, Kushner V P, Fel' V Ia

出版信息

Tsitologiia. 1990;32(3):291-4.

Abstract

The expression of membrane hetero-organic antigens of kidney origin, associated with the rat hepatomas in primary culture of intact adult rat hepatocytes, was investigated by means of the indirect immunofluorescence method using a specific immune serum. These antigens were observed on the membrane of some hepatocytes after their contact with nonhistone chromosomal proteins (NHCP), which were obtained from the kidney of intact rats from cells of hepatoma 27 and Zajdela hepatoma, or from the carcinogenic liver after a single diethylnitrosamine injection. Negative results were obtained after the incubation of hepatocytes in the medium lacking some of NHCP, or in that with NHCP obtained from the liver of intact rats.

摘要

采用间接免疫荧光法，使用特异性免疫血清，对完整成年大鼠肝细胞原代培养中与大鼠肝癌相关的肾源性膜异质性有机抗原的表达进行了研究。在一些肝细胞与非组蛋白染色体蛋白（NHCP）接触后，在其细胞膜上观察到了这些抗原，这些非组蛋白染色体蛋白取自完整大鼠的肾脏、肝癌27细胞和扎伊德氏肝癌细胞，或取自单次注射二乙基亚硝胺后的致癌肝脏。在缺乏某些NHCP的培养基中培养肝细胞，或在含有取自完整大鼠肝脏的NHCP的培养基中培养肝细胞后，得到了阴性结果。

相似文献

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[The effect of preparations of non-histone chromosomal proteins on the expression of hetero-organic membrane antigens of kidney origin in a primary rat hepatocyte culture].[非组蛋白染色体蛋白制剂对原代大鼠肝细胞培养中肾脏来源的异种有机膜抗原表达的影响]

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