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3,5-二甲基-1-{2-[(5-甲基-1,3,4-噻二唑-2-基)硫烷基]乙酰基}-2,6-二苯基哌啶-4-酮

3,5-Dimethyl-1-{2-[(5-methyl-1,3,4-thia-diazol-2-yl)sulfan-yl]acet-yl}-2,6-diphenylpiperidin-4-one.

作者信息

Ganesan S, Sugumar P, Ananthan S, Ponnuswamy M N

机构信息

Research Development Centre, Orchid Chemicals and Pharmaceuticals Ltd, Sozhinganallur, Chennai 600 119, India ; Department of Chemistry, Presidency College (Autonomous), Chennai 600 005, India.

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2013 May 11;69(Pt 6):o845. doi: 10.1107/S1600536813012014. Print 2013 Jun 1.

DOI:10.1107/S1600536813012014
PMID:23795032
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3684930/
Abstract

In the title compound, C24H25N3O2S2, the piperidine ring adopts a distorted boat conformation. The phenyl rings subtend angles of 75.6 (1)° and 86.3 (1)° with the mean plane of the piperidine ring. In the crystal, mol-ecules are linked through a network C-H⋯N hydrogen bonds, forming zigzag chains along [100]. The thia-diazol ring methyl group is disordered over two positions with an occupancy ratio of 0.69 (4):0.31 (4).

摘要

在标题化合物C₂₄H₂₅N₃O₂S₂中，哌啶环呈扭曲的船式构象。苯环与哌啶环的平均平面所成角度分别为75.6 (1)°和86.3 (1)°。在晶体中，分子通过C—H⋯N氢键网络相连，沿[100]方向形成锯齿链。噻二唑环甲基在两个位置上无序，占有率为0.69 (4):0.31 (4)。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f49/3684930/3412901f49ff/e-69-0o845-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f49/3684930/3ce73fb86235/e-69-0o845-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f49/3684930/f12d85028d27/e-69-0o845-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f49/3684930/3412901f49ff/e-69-0o845-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f49/3684930/3ce73fb86235/e-69-0o845-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f49/3684930/f12d85028d27/e-69-0o845-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f49/3684930/3412901f49ff/e-69-0o845-fig3.jpg

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本文引用的文献

1
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Acta Crystallogr D Biol Crystallogr. 2009 Feb;65(Pt 2):148-55. doi: 10.1107/S090744490804362X. Epub 2009 Jan 20.
2
Synthesis and spectral characterization of a new class of N-(N-methylpiperazinoacetyl)-2,6-diarylpiperidin-4-ones: antimicrobial, analgesic and antipyretic studies.一类新型N-(N-甲基哌嗪基乙酰基)-2,6-二芳基哌啶-4-酮的合成与光谱表征：抗菌、镇痛和解热研究
Eur J Med Chem. 2009 Feb;44(2):577-92. doi: 10.1016/j.ejmech.2008.03.031. Epub 2008 Apr 7.
3
A short history of SHELX.
SHELX简史。
Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22. doi: 10.1107/S0108767307043930. Epub 2007 Dec 21.