胰岛素联合可乐定激发试验对儿童生长激素缺乏症的诊断价值
Diagnostic value of provocative test by insulin combined with clonidine for growth hormone deficiency in children.
作者信息
Guo Cheng, Chen Li
机构信息
Department of Pediatrics of the Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
出版信息
Iran J Pediatr. 2013 Jun;23(3):315-20.
Abstract
OBJECTIVE
To evaluate the diagnostic value of provocative test by insulin combined with clonidine for growth hormone deficiency (GHD) during childhood.
METHODS
Eighty children underwent a provocative test with insulin(0.075U/Kg, intravenous) combined with clonidine (4μg/kg, orally). Among them, 40 children underwent clonidine provocative test, 40 children underwent insulin tolerance test (ITT) in another day.
FINDINGS
The specificity of ITT+clonidine test (74%, 88%) was remarkably higher than that of ITT (48%) or clonidine test (65%). ITT+clonidine test had a better accuracy (75%, 85%) than that of ITT (63%) or clonidine test (73%).
CONCLUSION
We conclude that the combined clonidine+insulin test is a feasible, reliable, convenient, time saving, and safe tool for evaluation of the growth hormone (GH) axes than the clonidine test or ITT.
摘要
目的
评估胰岛素联合可乐定激发试验对儿童生长激素缺乏症（GHD）的诊断价值。
方法
80名儿童接受了胰岛素（0.075U/Kg，静脉注射）联合可乐定（4μg/kg，口服）激发试验。其中，40名儿童接受可乐定激发试验，另外40名儿童在另一天接受胰岛素耐量试验（ITT）。
结果
ITT+可乐定试验的特异性（74%，88%）显著高于ITT（48%）或可乐定试验（65%）。ITT+可乐定试验的准确性（75%，85%）优于ITT（63%）或可乐定试验（73%）。
结论
我们得出结论，与可乐定试验或ITT相比，可乐定+胰岛素联合试验是一种评估生长激素（GH）轴的可行、可靠、方便、省时且安全的工具。
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