核受体共激活因子：大脑与行为中类固醇作用的调节因子。
Nuclear receptor coactivators: regulators of steroid action in brain and behaviour.
作者信息
Tetel M J, Acharya K D
机构信息
Neuroscience Program, Wellesley College, Wellesley, MA, USA.
出版信息
J Neuroendocrinol. 2013 Nov;25(11):1209-18. doi: 10.1111/jne.12065.
Abstract
Steroid hormones act in specific regions of the brain to alter behaviour and physiology. Although it has been well established that the bioavailability of the steroid and the expression of its receptor is critical for understanding steroid action in the brain, the importance of nuclear receptor coactivators in the brain is becoming more apparent. The present review focuses on the function of the p160 family of coactivators, which includes steroid receptor coactivator-1 (SRC-1), SRC-2 and SRC-3, in steroid receptor action in the brain. The expression, regulation and function of these coactivators in steroid-dependent gene expression in both brain and behaviour are discussed.
摘要
类固醇激素作用于大脑的特定区域，以改变行为和生理机能。尽管类固醇的生物利用度及其受体的表达对于理解类固醇在大脑中的作用至关重要这一点已得到充分证实，但核受体共激活因子在大脑中的重要性正变得愈发明显。本综述聚焦于共激活因子p160家族的功能，该家族包括类固醇受体共激活因子-1（SRC-1）、SRC-2和SRC-3，探讨其在大脑中类固醇受体作用方面的功能。文中讨论了这些共激活因子在大脑和行为中类固醇依赖性基因表达的表达、调控及功能。
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