Mohamed Tarek Mostafa, Salama Afrah F, El Nimr Tarek M, El Gamal Doaa M
Biochemistry Division, Chemistry Department, Faculty of Science, Tanta University, Tanta, Egypt
Biochemistry Division, Chemistry Department, Faculty of Science, Tanta University, Tanta, Egypt.
Toxicol Ind Health. 2015 Dec;31(12):1258-68. doi: 10.1177/0748233713485887. Epub 2013 Jun 24.
Cadmium (Cd) is one of the most dangerous occupational and environmental toxins. The objective of the present study is to examine the potential prophylactic effects of phytic acid (PA) on thyroid hormones of male rats intoxicated with Cd. The male albino rats were divided into five groups: group I (control) was fed with the basal diet, group II was intoxicated with Cd in drinking water, groups III, IV, and V were intoxicated with Cd in drinking water and fed with the diet containing 3.5, 7, and 10 g of PA/kg, respectively. The results indicated that the serum calcium, iron (Fe), and total Fe binding capacity levels and serum T3 and T4 in Cd-treated rats of group II were decreased when compared with the control group, while PA-administered groups with Cd showed a significant improvement when compared with the Cd-treated rats only. Serum thyroid stimulating hormone (TSH) level was significantly increased in Cd-treated rats compared with the control group, while the addition of PA in diet decreased the high levels of TSH. These results indicated a prophylactic effect of PA against Cd-induced toxicity in rats.
镉（Cd）是最危险的职业和环境毒素之一。本研究的目的是检测植酸（PA）对镉中毒雄性大鼠甲状腺激素的潜在预防作用。雄性白化大鼠被分为五组：第一组（对照组）喂食基础日粮，第二组饮用含镉的水，第三组、第四组和第五组饮用含镉的水，并分别喂食含3.5、7和10克PA/千克的日粮。结果表明，与对照组相比，第二组镉处理大鼠的血清钙、铁（Fe）、总铁结合能力水平以及血清T3和T4降低，而与仅镉处理的大鼠相比，添加PA的镉处理组有显著改善。与对照组相比，镉处理大鼠的血清促甲状腺激素（TSH）水平显著升高，而日粮中添加PA可降低高水平的TSH。这些结果表明PA对大鼠镉诱导的毒性有预防作用。
