Section of Gastroenterology and Nutrition, Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
J Investig Med. 2013 Aug;61(6):1036-8. doi: 10.2310/JIM.0b013e31829a4e25.
The incidence and prevalence of pediatric inflammatory bowel disease (IBD) seems to be increasing in North America and Europe. Our objective was to evaluate hospitalization rates in children with IBD in the United States during the decade 2000 to 2009.
We analyzed cases with a discharge diagnosis of Crohn disease (CD) and ulcerative colitis (UC) within the Healthcare Cost and Utilization Project Kids' Inpatient Database, Agency for Healthcare Research and Quality.
We identified 61,779 pediatric discharges with a diagnosis of IBD (CD, 39,451 cases; UC, 22,328 cases). The number of hospitalized children with IBD increased from 11,928 to 19,568 (incidence, 43.5-71.5 cases per 10,000 discharges per year; P < 0.001). For CD, the number increased from 7757 to 12,441 (incidence, 28.3-45.0; P < 0.001) and for UC, 4171 to 7127 (15.2-26.0; P < 0.001). Overall, there was a significant increasing trend for pediatric hospitalizations with IBD, CD, and UC (P < 0.001). In addition, there was an increase in IBD-related complications and comorbid disease burden (P < 0.01).
There was a significant increase in the number and incidence of hospitalized children with IBD in the United States from 2000 to 2009.
儿科炎症性肠病（IBD）的发病率和流行率在北美和欧洲似乎呈上升趋势。我们的目的是评估 2000 年至 2009 年期间美国儿童 IBD 的住院率。
我们分析了医疗保健成本和利用项目儿童住院数据库（Agency for Healthcare Research and Quality）中患有克罗恩病（CD）和溃疡性结肠炎（UC）的病例。
我们共确定了 61779 例患有 IBD（CD 39451 例，UC 22328 例）的儿科出院病例。患有 IBD 的住院儿童人数从 11928 例增加到 19568 例（发病率为每年每 10000 例出院病例 43.5-71.5 例；P<0.001）。对于 CD，从 7757 例增加到 12441 例（发病率为 28.3-45.0；P<0.001），对于 UC，从 4171 例增加到 7127 例（15.2-26.0；P<0.001）。总体而言，IBD、CD 和 UC 的儿科住院率呈显著上升趋势（P<0.001）。此外，IBD 相关并发症和合并症负担也有所增加（P<0.01）。
2000 年至 2009 年期间，美国患有 IBD 的住院儿童人数和发病率显著增加。
