双氢麦角毒碱对大鼠某些多巴胺相关行为的影响。

Effects of dihydroergotoxine on some dopamine-related behaviors in rats.

Flório J C, Palermo-Neto J

Applied Pharmacology and Toxicology Laboratory School of Veterinary Medicine, University of São Paulo, Brazil.

Gen Pharmacol. 1990;21(4):411-5. doi: 10.1016/0306-3623(90)90690-n.

Abstract

The effects of dihydroergotoxine on open-field behavior, apomorphine-induced stereotype and haloperidol-induced catalepsy were studied quantitatively in rats. 2. Dihydroergotoxine decreased the open-field behavior of rats, in a dose-dependent manner; this effect remained at least for 8 hr. 3. Dihydroergotoxine (10.0 mg/kg) caused a 1.40 leftward displacement of the dose-response curve constructed for apomorphine-induced stereotypy; the ED50 for apomorphine was reduced from 0.40 (+/- 0.05) to 0.29 (+/- 0.03). 4. Dihydroergotoxine (10.0 mg/kg) was unable to change haloperidol-induced catalepsy. 5. Results were discussed in the light of a possible interference of central noradrenergic systems with the expression of dopaminergic behaviors.

摘要

研究了双氢麦角毒碱对大鼠旷场行为、阿扑吗啡诱发的刻板行为和氟哌啶醇诱发的僵住症的影响。2. 双氢麦角毒碱以剂量依赖方式降低大鼠的旷场行为；该效应至少持续8小时。3. 双氢麦角毒碱（10.0毫克/千克）使阿扑吗啡诱发刻板行为的剂量-反应曲线向左位移1.40；阿扑吗啡的半数有效剂量（ED50）从0.40（±0.05）降至0.29（±0.03）。4. 双氢麦角毒碱（10.0毫克/千克）未能改变氟哌啶醇诱发的僵住症。5. 根据中枢去甲肾上腺素能系统对多巴胺能行为表达可能产生的干扰对结果进行了讨论。