细胞外钙对双去氧卡那霉素和地尔硫䓬在大鼠膈半横膈肌制备中对间接诱发强直反应的影响。

Influence of extracellular calcium in the effects of dibekacin and diltiazem on indirectly elicited tetanic responses in the rat phrenic-hemidiaphragm preparation.

Baños J E, Bosch F, Badia A

Departament de Farmacologia i Psiquiatria, Universitat Autònoma de Barcelona, Spain.

Gen Pharmacol. 1990;21(4):521-5. doi: 10.1016/0306-3623(90)90708-t.

Abstract

Dibekacin (70 microM-3 mM) produced a decrease of peak tetanic tension in a concentration-dependent manner and this effect was dependent on extracellular calcium (0.3-2.5 mM Ca2+). Only minimal fade was observed and it was not related with extracellular calcium concentrations. 2. Diltiazem (30-300 microM) decreased peak tetanic tension and produced tetanic fade. Both effects were independent of extracellular calcium, although a significant potentiation was observed at 0.3 mM calcium. 3. It is concluded that tetanic parameters are related differently to extracellular calcium.

摘要

地贝卡星（70微摩尔/升至3毫摩尔/升）以浓度依赖性方式使强直收缩峰值张力降低，且该效应依赖于细胞外钙（0.3毫摩尔/升至2.5毫摩尔/升钙离子）。仅观察到极小的衰减，且其与细胞外钙浓度无关。2. 地尔硫䓬（30微摩尔/升至300微摩尔/升）降低强直收缩峰值张力并产生强直收缩衰减。两种效应均与细胞外钙无关，尽管在0.3毫摩尔/升钙时观察到显著的增强作用。3. 得出的结论是，强直参数与细胞外钙的关系不同。