Fujiwara T, Takenaka S
Research Laboratories, Toyo Jozo Co., Ltd., Shizuoka, Japan.
FEMS Microbiol Lett. 1990 May;57(1-2):101-3. doi: 10.1016/0378-1097(90)90421-l.
Bioconversion of 19-deformyl-5-O-desosaminyl tylonolide (1) to 19-deformyl-4'-deoxydesmycosin (3) was performed by using a mycinamicin-producing Micromonospora species. Compound 1 at low concentrations was completely converted to compound 3, however, the conversion to compound 3 was suppressed at high concentrations and 19-deformyl-4'-deoxy-2", 3'-di-O-demethyl-desmycosin (2), an intermediate leading to compound 3 accumulated.
利用一株产麦白霉素的小单孢菌将19-去甲酰基-5-O-去氧胺基泰洛内酯（1）生物转化为19-去甲酰基-4'-脱氧柱晶白霉素（3）。低浓度的化合物1可完全转化为化合物3，然而，高浓度时向化合物3的转化受到抑制，积累了一种导致化合物3的中间体19-去甲酰基-4'-脱氧-2",3'-二-O-去甲基-柱晶白霉素（2）。
