Romano M, Diomede L, Guiso G, Caccia S, Perego C, Salmona M
Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.
Food Chem Toxicol. 1990 May;28(5):317-21. doi: 10.1016/0278-6915(90)90105-v.
Two doses (250 and 1000 mg/kg body weight) of aspartame were administered orally to male rats, and plasma and brain phenylalanine and tyrosine kinetic profiles were studied. In both plasma and brain the maximum increase in phenylalanine and tyrosine levels was reached 60 min after treatment. The changes in brain levels of phenylalanine or tyrosine 0, 60, 120 or 180 min after treatment with 1000 mg AMP/kg were directly correlated with the ratio of the plasma concentration of phenylalanine or tyrosine to the overall plasma concentration of the other large neutral amino acids. The time course of monoamine and metabolite concentrations, in the corpora striatum of the brain, was studied after an oral dose of 500 mg phenylalanine/kg. No significant modifications of monoamine levels were found at any of the times studied, up to 5 hr after dosing.
给雄性大鼠口服两剂（250和1000毫克/千克体重）阿斯巴甜，并研究血浆和脑内苯丙氨酸和酪氨酸的动力学曲线。在血浆和脑中，治疗后60分钟时苯丙氨酸和酪氨酸水平达到最大增幅。用1000毫克/千克阿斯巴甜治疗后0、60、120或180分钟时，脑内苯丙氨酸或酪氨酸水平的变化与血浆中苯丙氨酸或酪氨酸浓度与其他大中性氨基酸的总体血浆浓度之比直接相关。口服500毫克苯丙氨酸/千克后，研究了脑纹状体内单胺和代谢物浓度的时间进程。给药后长达5小时的任何研究时间点均未发现单胺水平有显著变化。
