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本文引用的文献

1
Recombinant vascular endothelial growth factor 121 infusion lowers blood pressure and improves renal function in rats with placentalischemia-induced hypertension.重组血管内皮生长因子 121 输注降低胎盘缺血诱导高血压大鼠的血压并改善肾功能。
Hypertension. 2010 Feb;55(2):380-5. doi: 10.1161/HYPERTENSIONAHA.109.141937. Epub 2009 Dec 21.
2
A randomised, double-blinded, placebo-controlled study of the phosphodiesterase type 5 inhibitor sildenafil for the treatment of preeclampsia.一项关于5型磷酸二酯酶抑制剂西地那非治疗先兆子痫的随机、双盲、安慰剂对照研究。
Hypertens Pregnancy. 2009 Aug;28(4):369-82. doi: 10.3109/10641950802601278.
3
The effects of sildenafil citrate (Viagra) on uterine blood flow and well being in the intrauterine growth-restricted fetus.枸橼酸西地那非（万艾可）对宫内生长受限胎儿子宫血流及健康状况的影响。
Am J Obstet Gynecol. 2009 Jan;200(1):102.e1-7. doi: 10.1016/j.ajog.2008.08.029. Epub 2008 Oct 9.
4
Changes in regional fetal cerebral blood flow perfusion in relation to hemodynamic deterioration in severely growth-restricted fetuses.严重生长受限胎儿的局部胎儿脑血流灌注变化与血流动力学恶化的关系。
Ultrasound Obstet Gynecol. 2008 Jul;32(1):71-6. doi: 10.1002/uog.5377.
5
Sildenafil citrate decreased natural killer cell activity and enhanced chance of successful pregnancy in women with a history of recurrent miscarriage.枸橼酸西地那非降低了自然杀伤细胞活性，并增加了有复发性流产史女性成功妊娠的几率。
Fertil Steril. 2008 Nov;90(5):1848-53. doi: 10.1016/j.fertnstert.2007.08.043. Epub 2008 Apr 28.
6
Nitric oxide and peroxynitrite platelet levels in women with small-for-gestational-age fetuses.小于胎龄儿女性的一氧化氮和过氧亚硝酸盐血小板水平
BJOG. 2008 Jan;115(1):14-21. doi: 10.1111/j.1471-0528.2007.01567.x.
7
Effects of sildenafil on the fetal growth of guinea pigs and their ability to survive induced intrapartum asphyxia.西地那非对豚鼠胎儿生长及其在分娩期窒息诱导下生存能力的影响。
Am J Obstet Gynecol. 2008 Jan;198(1):127.e1-6. doi: 10.1016/j.ajog.2007.06.068. Epub 2007 Oct 22.
8
Phosphodiesterase-5 inhibitors and omental and placental small artery function in normal pregnancy and pre-eclampsia.磷酸二酯酶-5抑制剂与正常妊娠和子痫前期的网膜及胎盘小动脉功能
Eur J Obstet Gynecol Reprod Biol. 2006 Jul;127(1):41-9. doi: 10.1016/j.ejogrb.2004.06.014.
9
Doppler sonography of the uterine and the cubital arteries in normal pregnancies, preeclampsia and intrauterine growth restriction: evidence for a systemic vessel involvement.
J Perinat Med. 2006;34(2):139-44. doi: 10.1515/JPM.2006.025.
10
Sildenafil citrate (Viagra) enhances vasodilatation in fetal growth restriction.枸橼酸西地那非（万艾可）可增强胎儿生长受限中的血管舒张作用。
J Clin Endocrinol Metab. 2005 May;90(5):2550-5. doi: 10.1210/jc.2004-1831. Epub 2005 Feb 15.

枸橼酸西地那非与胎儿生长受限中的子宫胎盘灌注

Sildenafil citrate and uteroplacental perfusion in fetal growth restriction.

作者信息

Dastjerdi Marzieh Vahid, Hosseini Sayedehafagh, Bayani Leila

机构信息

Department of Obstetrics and Gynecology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran ; Iranian Ministry of Health and Medical Education, Tehran, Iran.

出版信息

J Res Med Sci. 2012 Jul;17(7):632-6.

PMID:23798922
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3685778/
Abstract

BACKGROUND

To determine whether the phosphodiesterase type 5 inhibitor, Sildenafil citrate, affects uteroplacental perfusion.

MATERIALS AND METHODS

Based on a randomized double-blinded and placebo-controlled trial, forty one pregnant women with documented intrauterine growth retardation at 24-37 weeks of gestation were evaluated for the effect of a single dose of Sildenafil citrate on uteroplacental circulation as determined by Doppler ultrasound study of the umbilical and middle cerebral arteries. Statistical analysis included χ(2)-test to compare proportions, and independent-samples t-test and paired student's t-test to compare continuous variables.

RESULTS

Sildenafil group fetuses demonstrated a significant decrease in systolic/diastolic ratios (0.60 [SD 0.40] [95% Cl 0.37-0.84], P=0.000), and pulsatility index (0.12 [SD 0.15] [95% Cl 0.02-0.22], P=0.019) for the umbilical artery and a significant increase in middle cerebral artery pulsatility index (MCA PI) (0.51 [SD 0.60] [95% Cl 0.16-0.85], P=0.008).

CONCLUSION

Doppler velocimetry index values reflect decreased placental bed vascular resistance after Sildenafil. Sildenafil citrate can improve fetoplacental perfusion in pregnancies complicated by intrauterine growth restriction. It could be a potential therapeutic strategy to improve uteroplacental blood flow in pregnancies with fetal growth restriction (FGR).

摘要

背景

确定5型磷酸二酯酶抑制剂枸橼酸西地那非是否影响子宫胎盘灌注。

材料与方法

基于一项随机双盲安慰剂对照试验，对41例妊娠24 - 37周有宫内生长受限记录的孕妇进行评估，通过对脐动脉和大脑中动脉的多普勒超声研究，确定单剂量枸橼酸西地那非对子宫胎盘循环的影响。统计分析包括用于比较比例的χ²检验，以及用于比较连续变量的独立样本t检验和配对学生t检验。

结果

西地那非组胎儿脐动脉的收缩/舒张比（0.60 [标准差0.40] [95%可信区间0.37 - 0.84]，P = 0.000）和搏动指数（0.12 [标准差0.15] [95%可信区间0.02 - 0.22]，P = 0.019）显著降低，大脑中动脉搏动指数（MCA PI）显著升高（0.51 [标准差0.60] [95%可信区间0.16 - 0.85]，P = 0.008）。

结论

多普勒测速指数值反映了西地那非治疗后胎盘床血管阻力降低。枸橼酸西地那非可改善合并宫内生长受限妊娠的胎儿胎盘灌注。它可能是改善胎儿生长受限（FGR）妊娠子宫胎盘血流的一种潜在治疗策略。