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在韩国抑郁患者中，5-羟色胺受体 2C-759C/T 多态性与体重变化或米氮平治疗反应无相关性。

No Association between Serotonin Receptor 2C-759C/T Polymorphism and Weight Change or Treatment Response to Mirtazapine in Korean Depressive Patients.

机构信息

Department of Psychiatry, College of Medicine, Soonchunhyang University, Cheonan, Republic of Korea.

出版信息

Psychiatry Investig. 2013 Jun;10(2):190-5. doi: 10.4306/pi.2013.10.2.190. Epub 2013 May 30.

DOI:10.4306/pi.2013.10.2.190
PMID:23798968
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3687054/
Abstract

OBJECTIVE

Activation of one or more serotonin (5-HT) receptors may play a role in mediating the antidepressant effects of serotonergic antidepressants. The serotonin 2C (5HT 2C) receptor is known to be associated with antidepressant action and weight gain. We sought to determine whether the 5-HTR 2C receptor -759C/T polymorphism was associated with weight gain and treatment response to mirtazapine in major depressive disorder (MDD) patients.

METHODS

The 5-HT 2C receptor -759C/T polymorphism was analyzed in 323 MDD patients. All patients were evaluated using the 21-item Hamilton Depression Rating Scale at the beginning of the study and at 1, 2, 4, and 8 weeks of mirtazapine treatment.

RESULTS

There was no significant difference in the 5-HT 2C receptor -759C/T genotype distribution between responder and non-responder groups. The 5-HT 2C receptor -759C/T polymorphism was not associated with weight change over time after mirtazapine administration.

CONCLUSION

The 5-HT 2C receptor -759C/T polymorphism does not appear to be a predictor of treatment response to mirtazapine. This polymorphism was not associated with weight change after 8 weeks of mirtazapine treatment. Further investigation on other polymorphisms of the 5-HT 2C gene is required to determine whether the 5-HT 2C gene influences treatment response and weight change after mirtazapine administration in patients with major depressive disorder.

摘要

目的

激活一个或多个 5-羟色胺（5-HT）受体可能在介导 5-羟色胺能抗抑郁药的抗抑郁作用中发挥作用。已知 5-羟色胺 2C（5HT 2C）受体与抗抑郁作用和体重增加有关。我们试图确定 5-羟色胺 2C 受体-759C/T 多态性是否与 5-羟色胺 2C 受体-759C/T 多态性与体重增加和米氮平治疗抑郁症患者的反应有关。

方法

在 323 例 MDD 患者中分析了 5-HT 2C 受体-759C/T 多态性。所有患者在研究开始时以及米氮平治疗 1、2、4 和 8 周时均使用 21 项汉密尔顿抑郁评定量表进行评估。

结果

应答组和无应答组之间 5-HT 2C 受体-759C/T 基因型分布无显着差异。米氮平给药后，5-HT 2C 受体-759C/T 多态性与体重随时间的变化无关。

结论

5-HT 2C 受体-759C/T 多态性似乎不是米氮平治疗反应的预测因子。该多态性与米氮平治疗 8 周后体重变化无关。需要进一步研究 5-HT 2C 基因的其他多态性，以确定 5-HT 2C 基因是否影响米氮平治疗后抑郁症患者的治疗反应和体重变化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30a9/3687054/4746d1b4c2b1/pi-10-190-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30a9/3687054/e99b2d05ea2f/pi-10-190-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30a9/3687054/4746d1b4c2b1/pi-10-190-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30a9/3687054/e99b2d05ea2f/pi-10-190-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30a9/3687054/4746d1b4c2b1/pi-10-190-g002.jpg

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Psychiatry Investig. 2014 Jul;11(3):342-3. doi: 10.4306/pi.2014.11.3.342. Epub 2014 Jul 21.

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Olanzapine-induced weight gain is associated with the -759C/T and -697G/C polymorphisms of the HTR2C gene.奥氮平所致体重增加与5-羟色胺2C受体（HTR2C）基因的-759C/T和-697G/C多态性有关。
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