PDE4D 基因遗传多态性与中国人群缺血性脑卒中风险的荟萃分析。
Genetic polymorphism in PDE4D gene and risk of ischemic stroke in Chinese population: a meta-analysis.
机构信息
Department of Neurology, First Affiliated Hospital of China Medical University, Shenyang, China.
出版信息
PLoS One. 2013 Jun 17;8(6):e66374. doi: 10.1371/journal.pone.0066374. Print 2013.
BACKGROUND
Stroke is the second most common cause of death and major cause of disability worldwide. The SNP 83 in PDE4D gene has been suggested as a risk factor in ischemic stroke, but direct evidence from genetic association studies remains inconclusive even in Chinese population.
METHODS
Meta-analysis of case-control studies on the relationship between SNP 83 in PDE4D gene and susceptibility to ischemic stroke in Chinese population published domestically and abroad from January 2003 to September 2012.
RESULTS
9 case-control studies were selected. Meta-analysis results showed that the significant association between SNP 83 and ischemic stroke was found under the dominant model (OR = 1.34, 95% CI: 1.20-1.49) and recessive model (OR = 1.45, 95% CI: 1.19-1.76) in Chinese population. In subgroup meta-analysis, SNP 83 and atherothrombotic stroke, rather than lacunar stroke, showed the significant association under the dominant model (OR = 1.69, 95% CI: 1.41-2.01) and recessive model (OR = 1.47, 95% CI: 1.04-2.06).
CONCLUSIONS
The results suggest that SNP 83 in PDE4D gene is significantly associated with susceptibility to ischemic stroke in Chinese population.
背景
卒中是全球范围内第二大致死原因和主要致残原因。PDE4D 基因中的 SNP83 被认为是缺血性卒中的风险因素，但即使在中国人种中，遗传关联研究的直接证据仍不确定。
方法
对 2003 年 1 月至 2012 年 9 月国内外发表的关于 PDE4D 基因 SNP83 与中国人群缺血性卒中易感性关系的病例对照研究进行荟萃分析。
结果
共纳入 9 项病例对照研究。Meta 分析结果显示，在中国人种中，SNP83 与缺血性卒中在显性模型（OR=1.34，95%CI：1.20-1.49）和隐性模型（OR=1.45，95%CI：1.19-1.76）下存在显著关联。亚组 Meta 分析显示，在显性模型（OR=1.69，95%CI：1.41-2.01）和隐性模型（OR=1.47，95%CI：1.04-2.06）下，SNP83 与动脉粥样硬化性卒中和腔隙性卒中而非腔隙性卒中存在显著关联。
结论
结果表明，PDE4D 基因中的 SNP83 与中国人群缺血性卒中易感性显著相关。
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