School of Nursing, University of Missouri-Kansas City, Kansas City, Missouri 64108, USA.
J Womens Health (Larchmt). 2013 Aug;22(8):702-5. doi: 10.1089/jwh.2012.4180. Epub 2013 Jun 25.
This study was conducted to evaluate the therapeutic efficacy of a device designed to deliver high-frequency vibratory stimulation through direct intravaginal tampon application (VIPON) compared with a low-dose over-the-counter pharmacologic treatment of dysmenorrhea.
A randomized, open-label, prospective study comparing the investigational device to an oral self-administration of the over-the-counter dose of 200-400 mg of ibuprofen with the onset of menstrual discomfort was conducted at two academic medical centers in the Midwest region of the United States. Women age 18 and older with self-reported dysmenorrhea were treated with either VIPON or a single dose of 200-400 mg of ibuprofen, randomized for each of the next four menstrual cycles, and pain reduction from baseline was measured according to the Melzack-McGill pain scale.
Overall, both ibuprofen and VIPON have significant effects on pain reduction according to the Melzack-McGill pain scale. However, the VIPON group achieved statistically significant greater, and more rapid, pain relief at every time point when compared with the ibuprofen.
VIPON tampon is a viable, nonpharmacologic option to traditional low-dose over-the-counter pharmacologic therapies for menstrual pain management with more rapid onset of action.
本研究旨在评估一种通过直接阴道内塞应用（VIPON）输送高频振动刺激的设备的治疗效果，与低剂量非处方药物治疗痛经进行比较。
在美国中西部的两个学术医疗中心进行了一项随机、开放标签、前瞻性研究，将该研究设备与口服非处方剂量的 200-400 毫克布洛芬进行比较，当月经不适开始时进行治疗。年龄在 18 岁及以上、自我报告有痛经的女性，随机接受 VIPON 或单次口服 200-400 毫克布洛芬治疗，每个周期持续四个月经周期，并根据梅尔扎克-麦吉尔疼痛量表测量从基线的疼痛减轻程度。
总体而言，根据梅尔扎克-麦吉尔疼痛量表，布洛芬和 VIPON 对减轻疼痛都有显著效果。然而，与布洛芬相比，VIPON 组在每个时间点都达到了统计学上显著更大和更快的疼痛缓解。
VIPON 阴道塞是一种可行的、非药物的选择，可替代传统的低剂量非处方药物治疗月经疼痛，起效更快。
