Austin Cindy L, Finley Phillip J, Mikkelson Debbie R, Tibbs Brian
From the Division of Trauma and Burn Research, Mercy Hospital, Mercy Medical Research Institute, Springfield, Missouri.
J Burn Care Res. 2014 May-Jun;35(3):e164-71. doi: 10.1097/BCR.0b013e318299d4bb.
This article reviews four immunocompetent patients who developed a rare fungal infection, mucormycosis, secondary to multiple traumatic injuries sustained during an EF-5 tornado in Joplin, MO. Commonly found in soil and decaying organic matter, mucorales are fungi associated with soft tissue and cutaneous infections. Onset of this fungal infection can occur without clinical signs, presenting several days to several weeks after injury, delaying diagnosis. A multidisciplinary treatment approach including aggressive antifungal therapy and aggressive surgical debridement is critical. This diagnosis should be considered in all patients presenting with injuries sustained from high-velocity embedment of debris such as natural disasters or explosions. We present four cases of mucormycosis, species Apophysomyces trapeziformis. Data reported includes predisposing factors, number of days between injury and diagnosis of mucormycosis, surgical treatment, antifungal therapy, outcomes, and potential risk factors that may have contributed to the development of mucormycosis.
本文回顾了4例免疫功能正常的患者,他们在密苏里州乔普林市一场EF - 5级龙卷风期间遭受多处创伤后,继发了一种罕见的真菌感染——毛霉病。毛霉目真菌常见于土壤和腐烂的有机物中,与软组织和皮肤感染有关。这种真菌感染在发病时可能没有临床症状,在受伤后数天至数周出现,从而延误诊断。包括积极的抗真菌治疗和积极的手术清创在内的多学科治疗方法至关重要。对于所有因自然灾害或爆炸等高速度碎片嵌入而受伤的患者,均应考虑这一诊断。我们报告了4例梯形犁头霉引起的毛霉病病例。报告的数据包括易感因素、受伤至毛霉病诊断之间的天数、手术治疗、抗真菌治疗、结果以及可能导致毛霉病发生的潜在危险因素。