在血压正常的慢性阻塞性肺疾病患者中，血清胎球蛋白-A水平与颈动脉内膜中层厚度相关。

Serum fetuin-A levels are associated with carotid intima-media thickness in patients with normotensive chronic obstructive pulmonary disease.

作者信息

Alpsoy Seref, Akyuz Aydın, Mutlu Levent Cem, Oran Mustafa, Akkoyun Dursun Cayan, Topcu Birol, Degirmenci Hasan, Guze Savas

机构信息

Namık Kemal University, Faculty of Medicine, Tekirdağ, Turkey.

出版信息

Cardiol J. 2014;21(2):191-7. doi: 10.5603/CJ.a2013.0060. Epub 2013 Jun 25.

DOI:10.5603/CJ.a2013.0060

PMID:23799555

Abstract

BACKGROUND

There are contradictory reports about the relationship between fetuin-A and atherosclerotic process. Coronary artery disease is the most important cause of mortality in patients with chronic obstructive pulmonary disease (COPD). We aimed to investigate the association of serum fetuin-A level with mean carotid intima-media thickness (cIMT) and ankle-brachial index (ABI) in COPD.

METHODS

We evaluated the association of serum fetuin-A level, mean cIMT and ABI in normotensive subjects with COPD (n = 65) and with non-COPD (n = 50).

RESULTS

Fetuin-A level was significantly lower (63.5 ± 19.8 ng/mL, 72.9 ± 16.2 ng/mL, p = 0.035) and C-reactive protein level higher (4 [1-10] vs. 3 [1-12] mg/dL, p = 0.034) in COPD patients than the control group. Compared to controls, fetuin-A level was significantly lower (63.5 ± 19.8 ng/mL, 72.9 ± 16.2 ng/mL, p = 0.035) and mean cIMT higher (0.69 [0.50-0.98] vs. 0.62 [0.44-0.98] mm, p = 0.034, respectively) in the COPD group. There was a significant negative correlation between mean cIMT and fetuin-A levels (r = -0.320, p = 0.032). Age (b ± SE: 0.002 ± 0.001, p = 0.008) and fetuin-A (b ± SE: -0.002 ± 0.001, p = 0.035) were decisive for the mean cIMT.

CONCLUSIONS

There are increased cIMT values, decreased fetuin-A levels, but unchanged ABI values in patients with normotensive COPD. Age and fetuin-A were predictors for cIMT, while fetuin-A was negatively correlated with cIMT.

摘要

背景

关于胎球蛋白-A与动脉粥样硬化进程之间的关系，存在相互矛盾的报道。冠状动脉疾病是慢性阻塞性肺疾病（COPD）患者死亡的最重要原因。我们旨在研究COPD患者血清胎球蛋白-A水平与平均颈动脉内膜中层厚度（cIMT）和踝臂指数（ABI）之间的关联。

方法

我们评估了血压正常的COPD患者（n = 65）和非COPD患者（n = 50）的血清胎球蛋白-A水平、平均cIMT和ABI之间的关联。

结果

与对照组相比，COPD患者的胎球蛋白-A水平显著降低（63.5±19.8 ng/mL对72.9±16.2 ng/mL，p = 0.035），而C反应蛋白水平更高（4[1 - 10]对3[1 - 12]mg/dL，p = 0.034）。与对照组相比，COPD组的胎球蛋白-A水平显著降低（63.5±19.8 ng/mL对72.9±16.2 ng/mL，p = 0.035），平均cIMT更高（0.69[0.50 - 0.98]对0.62[0.44 - 0.98]mm，p分别为0.034）。平均cIMT与胎球蛋白-A水平之间存在显著负相关（r = -0.320，p = 0.032）。年龄（b±SE：0.002±0.001，p = 0.008）和胎球蛋白-A（b±SE：-0.002±0.001，p = 0.035）对平均cIMT起决定性作用。