Namik Kemal University, Faculty of Medicine, Department of Gynecology and Obstetrics, Tekirdag, Turkey.
Eur J Obstet Gynecol Reprod Biol. 2013 Jul;169(1):45-9. doi: 10.1016/j.ejogrb.2013.01.023. Epub 2013 Feb 19.
To investigate fetuin-A concentrations and its association with metabolic and sonographic cardiovascular markers in women with polycystic ovary syndrome (PCOS) and healthy subjects.
Thirty-five women with PCOS and 37 healthy control women were matched for body mass index (BMI) and age. Serum fetuin-A concentrations, and reproductive and adrenal hormones were measured, and insulin resistance and carotid intima media thickness (CIMT) were evaluated in both groups. The correlations between cardiovascular risk factors, CIMT and fetuin-A concentrations were tested.
Mean fetuin-A concentrations were significantly elevated in the PCOS group compared with control subjects (101.2 ng/ml ± 33.55 vs. 82.5 ng/ml ± 32.65, P=0.019). CIMT was also higher in women with PCOS than in control subjects (0.51 ± 0.05 mm vs. 0.44 ± 0.05 mm, P<0.01). Serum lipid parameters were correlated to serum fetuin-A concentrations in the PCOS group, but no correlation was found between fetuin-A and CIMT (rPCOS=0.244, pPCOS=0.158; rcontrol=-0.002, pcontrol=0.988).
In this, the first study of fetuin-A concentrations in PCOS, the results showed that fetuin-A concentrations were increased in euglycemic patients with PCOS.
研究多囊卵巢综合征（PCOS）女性和健康对照者的胎球蛋白-A 浓度及其与代谢和超声心血管标志物的关系。
将 35 名 PCOS 女性和 37 名健康对照女性按体重指数（BMI）和年龄匹配。评估两组患者的血清胎球蛋白-A 浓度、生殖和肾上腺激素水平，以及胰岛素抵抗和颈动脉内膜中层厚度（CIMT）。检测心血管危险因素、CIMT 与胎球蛋白-A 浓度之间的相关性。
与对照组相比，PCOS 组的平均胎球蛋白-A 浓度明显升高（101.2ng/ml ± 33.55 比 82.5ng/ml ± 32.65，P=0.019）。PCOS 组的 CIMT 也高于对照组（0.51 ± 0.05mm 比 0.44 ± 0.05mm，P<0.01）。PCOS 组的血清血脂参数与血清胎球蛋白-A 浓度相关，但胎球蛋白-A 与 CIMT 之间无相关性（rPCOS=0.244，pPCOS=0.158；rcontrol=-0.002，pcontrol=0.988）。
在这项对 PCOS 患者胎球蛋白-A 浓度的首次研究中，结果表明，血糖正常的 PCOS 患者的胎球蛋白-A 浓度升高。
