Leibovici V, Statter M, Weinrauch L, Tzfoni E, Matzner Y
Department of Dermatology, Hadassah University Hospital, Ein Kerem, Israel.
Isr J Med Sci. 1990 Jun;26(6):306-9.
Neutrophil chemotaxis in patients with psoriasis vulgaris and psoriatic arthritis was investigated before and after 6 weeks of treatment with zinc sulphate (50 mg elementary zinc three times daily). In patients with active psoriasis vulgaris, a significant increase in neutrophil random migration and directed chemotaxis was demonstrated (10.2 +/- 3.1 and 14.1 +/- 4.1 mu, respectively, greater than that of control patients), while in patients with psoriatic arthritis the values were within the normal range (5.8 +/- 3.2 and 1.1 +/- 4.1 mu, respectively, greater than that of control patients). Although the zinc sulphate treatment had little or no effect on the course of either disease, it restored both the random migration and directed chemotaxis to normal values in psoriasis vulgaris patients. These results support the contention that zinc sulphate modifies neutrophil inflammatory potential; however, the lack of a clinical benefit suggests that neutrophils play only a secondary role in the pathogenesis of psoriasis.
对寻常型银屑病和银屑病关节炎患者在接受硫酸锌（50毫克元素锌，每日三次）治疗6周前后的中性粒细胞趋化性进行了研究。在活动期寻常型银屑病患者中，中性粒细胞随机游走和定向趋化性显著增加（分别比对照患者高10.2±3.1和14.1±4.1微米），而银屑病关节炎患者的值在正常范围内（分别比对照患者高5.8±3.2和1.1±4.1微米）。尽管硫酸锌治疗对这两种疾病的病程几乎没有影响，但它使寻常型银屑病患者的随机游走和定向趋化性恢复到正常水平。这些结果支持硫酸锌改变中性粒细胞炎症潜能的观点；然而，缺乏临床益处表明中性粒细胞在银屑病发病机制中仅起次要作用。
