Christophers E, Schröder J M
Hautarzt. 1981 Nov;32(11):558-63.
The presence of polymorphonuclear neutrophils (PMN) is a constant feature of Psoriatic epidermis. The reasons for this migratory activity are not clear and may be related to the presence of chemotaxigens or chemoattractants (circulating immune complexes, complement split products, or arachidonic acid metabolites) in serum and/or epidermis. On the other hand, functional abnormalities of psoriatic PMN may play a significant role as well. PMN chemotaxis, e.g., against increased chemoattractants has been found to be significantly increased in psoriasis. On the basis of these findings it may be suggested, that potent chemotaxigens or chemoattractants together with hyperactive PMN by the liberation of lysosomal enzymes cause a self-augmented increase of chemotactic factors. Recent experiments using PMN and sera from patients with psoriasis appear to support this concept. Modulating influences of immunoglobulins, specifically immunoglobulin A have recently been discovered. In chronic stationary psoriasis chemotactic activity of PMN is strongly inhibited which appears to be due to increased levels of IgA. Further, in inflammatory dermatoses with predominantly neutrophils similar IgA-related chemotaxis depression has been found. This appears to be a newly found modulation of PMN-dependent inflammatory reactions in the skin.
多形核中性粒细胞（PMN）的存在是银屑病表皮的一个恒定特征。这种迁移活性的原因尚不清楚，可能与血清和/或表皮中趋化因子或化学引诱剂（循环免疫复合物、补体裂解产物或花生四烯酸代谢产物）的存在有关。另一方面，银屑病PMN的功能异常也可能起重要作用。例如，已发现银屑病中PMN趋化性，如对增加的化学引诱剂的趋化性显著增强。基于这些发现，可能有人提出，强效趋化因子或化学引诱剂与活跃的PMN一起通过溶酶体酶的释放导致趋化因子的自我增强增加。最近使用银屑病患者的PMN和血清进行的实验似乎支持这一概念。最近发现了免疫球蛋白，特别是免疫球蛋白A的调节作用。在慢性静止期银屑病中，PMN的趋化活性受到强烈抑制，这似乎是由于IgA水平升高所致。此外，在以中性粒细胞为主的炎症性皮肤病中也发现了类似的IgA相关趋化抑制。这似乎是皮肤中PMN依赖性炎症反应的一种新发现的调节作用。
