Cardiology, Clinical and Molecular Medicine Department, "Sapienza" University of Rome, Italy.
Cytokine Growth Factor Rev. 2013 Oct;24(5):411-25. doi: 10.1016/j.cytogfr.2013.05.008. Epub 2013 Jun 22.
Preeclampsia is the major cause of maternofetal and neonatal morbi-mortality including intrauterine growth retardation, miscarriages and stillbirths. Inadequate vascular dilation and angiogenesis represent the crucial underlying defect of gravidic hypertension, denoting a failed response to the vasodilatory and pro-angiogenic challenge imposed by pregnancy, especially if multifetal. A similar pathogenesis appears involved in gestational diabetes. In this review we aimed to provide a hint on understanding the deeply involved angiogenic disorders which eventually culminate in utero-placental failure. The key players in these complex processes may be found in an intricate network of growth factors (GFs) and GF inhibitors, controlled by several vascular risk factors modulated by environment and genes, which eventually impact on early and late cardiovascular outcomes of mother and fetus.
子痫前期是母婴和新生儿发病率和死亡率的主要原因，包括宫内生长受限、流产和死产。血管扩张不足和血管生成代表妊娠高血压的关键潜在缺陷，表明对妊娠引起的血管舒张和促血管生成挑战反应失败，尤其是多胎妊娠。类似的发病机制似乎与妊娠期糖尿病有关。在这篇综述中，我们旨在提供对最终导致胎盘功能不全的血管生成障碍的深入理解的线索。这些复杂过程中的关键参与者可能存在于生长因子（GFs）和 GF 抑制剂的复杂网络中，这些因子受环境和基因调节的多种血管危险因素控制，最终影响母亲和胎儿的早期和晚期心血管结局。
