Wiborg Ove
Deparment of Clinical Medicine, Aarhus University, Skovagervej 2, 8240, Risskov, Denmark,
Cell Tissue Res. 2013 Oct;354(1):155-69. doi: 10.1007/s00441-013-1664-0. Epub 2013 Jun 26.
Major depressive disorder is a complex disease implicating many brain circuitries. The clinical symptomatology is inconsistent and heterogenous and the pathogenesis is a complicated interplay of genetic and environmental factors. The episodic and recurrent nature of the disease, as well as the fact that several symptoms are only verbally expressed, make it challenging to establish valid and legitimate animal models of this disease. The purpose of this review is to provide some background knowledge and overview of valid rodent models of depression with an emphasis on our own experience with a chronic mild stress model in modeling of anhedonia and cognitive impairments associated with depression. In a final concluding remark, a 'dying-forward' hypothesis, for development of depression, is suggested on the basis of mainly our own data on a hippocampal pathology.
重度抑郁症是一种涉及多个脑回路的复杂疾病。其临床症状不一致且具有异质性，发病机制是遗传和环境因素的复杂相互作用。该疾病的发作性和复发性本质，以及一些症状仅通过言语表达这一事实，使得建立该疾病有效的、合理的动物模型具有挑战性。本综述的目的是提供一些关于抑郁症有效啮齿动物模型的背景知识和概述，重点是我们自己在慢性轻度应激模型中模拟与抑郁症相关的快感缺失和认知障碍方面的经验。在最后的总结中，基于我们自己关于海马体病理学的数据，提出了一个关于抑郁症发展的“渐进性死亡”假说。
