Krause Michael, Liu Jun
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.
Wiley Interdiscip Rev Dev Biol. 2012 Mar-Apr;1(2):203-14. doi: 10.1002/wdev.15. Epub 2011 Dec 8.
Myogenesis has proved to be a powerful paradigm for understanding cell fate specification and differentiation in many model organisms. Studies of somatic bodywall muscle (BWM) development in Caenorhabditis elegans allow us to define, with single cell resolution, the distinct hierarchies of transcriptional regulators needed for myogenesis throughout development. Although all 95 BWM cells appear uniform after differentiation, there are several different regulatory cascades employed embryonically and post-embryonically. These, in turn, are integrated into multiple extrinsic cell signaling events. The convergence of these different pathways on the key nodal point, that is the activation of the core muscle module, commits individual cells to myogenesis. Comparisons of myogenesis between C. elegans and other model systems provide insights into the evolution of contractile cell types, demonstrating the conservation of regulatory schemes for muscles throughout the animal kingdom.
在许多模式生物中，肌发生已被证明是理解细胞命运特化和分化的有力范例。对秀丽隐杆线虫体壁肌肉（BWM）发育的研究使我们能够以单细胞分辨率定义整个发育过程中肌发生所需的不同转录调节因子层次结构。尽管所有95个BWM细胞在分化后看起来是一致的，但在胚胎期和胚胎后期采用了几种不同的调节级联。这些调节级联又被整合到多个外在细胞信号事件中。这些不同途径在关键节点上的汇聚，即核心肌肉模块的激活，使单个细胞致力于肌发生。秀丽隐杆线虫与其他模式系统之间肌发生的比较为收缩细胞类型的进化提供了见解，证明了整个动物界肌肉调节机制的保守性。
