Ma Yu-Xiao, Li Wei-Hua, Xie Qiang
Department of Cardiology, First Affiliated Hospital of Xiamen University, China.
Pharmazie. 2013 May;68(5):355-8.
This study aimed to investigate the effects of rosuvastatin on TGF-beta1 expression, cardiac fibrosis, ventricular remodeling and cardiac function in diabetic cardiomyopathy rats. Twenty-seven diabetic rats induced by streptozotocin intraperitoneal injection were randomly divided into three groups, viz. diabetic, rosuvastatin low-dose (Ros-L) and high dose group (Ros-H). Intervention group were given rosuvastatin 2 mg/kg/d and 5 mg/kg/d orally, respectively. After 10 weeks, the levels of glycosylated hemoglobin (HbA1c), creatine phosphokinase isoenzyme (CK-MB), plasma brain natriuretic peptide (BNP), myocardial collagen volume fraction (CVF) and left ventricular mass index (LVWI) were measured. CK-MB levels in Ros-H and Ros-L rats were lower than in the diabetic group. Rosuvastatin alleviated myofibrosis cordis and fibroplastic proliferation. LVWI, BNP, CVF and TGF-beta1 mRNA and protein levels in the diabetic group were higher than in the control, but were reduced after rosuvastatin treatment. These results demonstrate that rosuvastatin dose-dependently reduces TGF-beta1 expression and inhibits the development of myocardial fibrosis in diabetic cardiomyopathy.
本研究旨在探讨瑞舒伐他汀对糖尿病性心肌病大鼠转化生长因子-β1（TGF-β1）表达、心脏纤维化、心室重构及心脏功能的影响。将27只经腹腔注射链脲佐菌素诱导的糖尿病大鼠随机分为三组，即糖尿病组、瑞舒伐他汀低剂量组（Ros-L）和高剂量组（Ros-H）。干预组分别给予瑞舒伐他汀2mg/kg/d和5mg/kg/d口服。10周后，检测糖化血红蛋白（HbA1c）、肌酸磷酸激酶同工酶（CK-MB）、血浆脑钠肽（BNP）、心肌胶原容积分数（CVF）及左心室质量指数（LVWI）水平。Ros-H组和Ros-L组大鼠的CK-MB水平低于糖尿病组。瑞舒伐他汀减轻了心肌纤维化和纤维增生。糖尿病组的LVWI、BNP、CVF以及TGF-β1 mRNA和蛋白水平高于对照组，但经瑞舒伐他汀治疗后降低。这些结果表明，瑞舒伐他汀可剂量依赖性降低TGF-β1表达，并抑制糖尿病性心肌病心肌纤维化的发展。
