[Nusap1在肝细胞癌手术切缘中的表达及其与早期复发的关系]
[Expression of Nusap1 in the surgical margins of hepatocellular carcinoma and its association with early recurrence].
作者信息
Zhang Meng, Yang Dinghua, Liu Xiao, Liu Yan, Liang Jiankui, He Hua, Zhong Kebo, Lin Liang, Tao Guogui, Zhang Chi, Zhou Jie
机构信息
Department of Hepatobiliary Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
出版信息
Nan Fang Yi Ke Da Xue Xue Bao. 2013 Jun;33(6):937-8, inside back cover.
OBJECTIVE
To detect the expression of Nusap1 of surgical margins in hepatocellular carcinoma (HCC) and investigate its association with early tumor recurrence.
METHODS
The expression of Nusap1 in the surgical margins of HCC, which were histopathologically negative for tumor cells, was examined using immunohistochemistry in 61 HCC cases.
RESULTS
Fifteen of 21 (71.4%) cases with immunohistochemical positivity for Nusap1 expression in the surgical margins had early recurrence of HCC, a rate significantly higher than that in patients with negative Nusap1 expression (12/40, 30%) (P<0.05).
CONCLUSIONS
Nusap1 expression in the surgical margins of HCC is closely correlated to early postoperative recurrence and can serve as an indicator for predicting early recurrence of HCC.
目的
检测肝细胞癌（HCC）手术切缘中Nusap1的表达，并探讨其与肿瘤早期复发的关系。
方法
采用免疫组织化学法检测61例HCC患者手术切缘中Nusap1的表达，这些手术切缘在组织病理学上未发现肿瘤细胞。
结果
手术切缘Nusap1表达免疫组化阳性的21例患者中，有15例（71.4%）出现HCC早期复发，这一比例显著高于Nusap1表达阴性的患者（12/40，30%）（P<0.05）。
结论
HCC手术切缘中Nusap1的表达与术后早期复发密切相关，可作为预测HCC早期复发的指标。
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