Department of Cardiothoracic Surgery, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
Eur J Cardiothorac Surg. 2013 Sep;44(3):e182-8. doi: 10.1093/ejcts/ezt308. Epub 2013 Jun 25.
As survival after cardiac surgery has become very satisfactory even in elderly patients, more attention is being directed towards improved health-related quality of life (HRQOL). However, longitudinal prospective cohort studies describing HRQOL after cardiac surgery are still scarce. The purpose of this study was to explore HRQOL and survival in patients undergoing cardiac surgery after 5 years, emphasizing on older patients (≥75 years).
In a prospective population-based study, 534 patients (23% ≥75 years, 67% males) were consecutively included before surgery. HRQOL and medical and sociodemographic variables were measured by questionnaires at baseline, 6 and 12 months after surgery and again after 5 years. HRQOL was measured by the Short-Form 36 Health Survey (SF-36).
Four hundred and fifty-eight patients were alive after 5 years, with a response rate of 82%. Older patients had lower 5-year survival than younger patients (P = 0.042), but it was similar to that of the general population. After 5 years, both older and younger patients had slightly lower scores on some SF-36 dimensions, compared with scores after 6 and 12 months. However, on seven of eight subscales of the SF-36, the scores after 5 years were still higher than before surgery. Older patients improved less from baseline to the follow-up, and had more profound reductions in scores from 12 months to 5 years on three subscales; physical functioning (P = 0.013), role physical (P < 0.001) and vitality (P = 0.036).
HRQOL improved from baseline to 6 months postoperatively, and remained relatively stable 5 years after cardiac surgery even in elderly patients. The study showed that survival and HRQOL can match that of the general population.
由于心脏手术后的生存率即使在老年患者中也变得非常令人满意,因此更多的注意力集中在提高与健康相关的生活质量(HRQOL)上。但是,描述心脏手术后 HRQOL 的纵向前瞻性队列研究仍然很少。本研究旨在探讨心脏手术后 5 年患者的 HRQOL 和生存率,重点关注老年患者(≥75 岁)。
在一项前瞻性的基于人群的研究中,连续纳入了 534 名患者(23%≥75 岁,67%为男性),在手术前进行了问卷调查。HRQOL 和医疗及社会人口统计学变量在基线时、手术后 6 个月和 12 个月以及 5 年后再次进行测量。HRQOL 通过 36 项简短健康调查(SF-36)进行测量。
5 年后有 458 名患者存活,应答率为 82%。与年轻患者相比,老年患者的 5 年生存率较低(P=0.042),但与一般人群相似。与术后 6 个月和 12 个月相比,5 年后,老年和年轻患者的一些 SF-36 维度的评分均略有下降。然而,在 SF-36 的八项子量表中的七项中,5 年后的评分仍高于手术前。老年患者从基线到随访的改善较少,并且在三个子量表(身体机能,角色身体和活力)上,从 12 个月到 5 年的评分下降更为明显(P=0.013,P<0.001,P=0.036)。
HRQOL 从基线开始改善,术后 6 个月达到高峰,即使在老年患者中,心脏手术后 5 年 HRQOL 仍相对稳定。该研究表明,生存率和 HRQOL 可以与一般人群相匹配。