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择期心脏手术后的长期生活质量和创伤后应激:一项5年随访研究的初步结果

Long-term quality of life and posttraumatic stress following elective cardiac surgery: preliminary findings of a 5-year follow-up study.

作者信息

Gražulytė Daiva, Kazlauskas Evaldas, Norkienė Ieva, Kolevinskaitė Smiltė, Kezytė Greta, Urbanavičiūtė Indrė, Sabestinaitė Akvilė, Korsakaitė Gintarė, Želvienė Paulina, Ringaitienė Donata, Šostakaitė Gintarė, Šipylaitė Jūratė

机构信息

Clinic of Anaesthesiology and Intensive Care, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.

Centre for Psychotraumatology, Institute of Psychology, Vilnius University, Vilnius, Lithuania.

出版信息

Acta Med Litu. 2019;26(1):87-92. doi: 10.6001/actamedica.v26i1.3960.

Abstract

BACKGROUND

Heart surgery is a major stressful event that can have a significant negative effect on patients' quality of life (QoL) and may cause long-term posttraumatic stress reactions. The aim of this pilot study was to estimate the longitudinal change and predictors of health-related quality of life (HRQOL) dynamics and identify factors associated with PTS at 5-year follow-up (T2) after elective cardiac surgery and associations with pre-surgery (T1) QoL.

MATERIALS AND METHODS

Single-centre prospective study was conducted after Regional Bioethics Committee approval. Adult consecutive patients undergoing elective cardiac surgery were included. HRQOL was measured using the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36) questionnaire before (T1) and 5-years after (T2) cardiac surgery. Posttraumatic stress was assessed using the International Trauma Questionnaire.

RESULTS

The pilot study revealed a significant positive change at 5-year follow-up in several domains of SF-36: physical functioning (PF), energy/fatigue (E/F), and social functioning (SF). Prolonged postoperative hospital stay was associated with change in SF ( < 0.01), E/F ( < 0.05) and emotional well-being ( < 0.05). The percentage of patients that had the posttraumatic stress disorder (PTSD) at T2 was 12.2%. Posttraumatic stress symptoms were associated with longer hospitalization after surgery ( < 0.01).

CONCLUSIONS

HRQOL improved from baseline to five years postoperatively. Patients with lower preoperative HRQOL scores tended to have a more significant improvement of HRQOL five years after surgery. A prolonged postoperative hospital stay had a negative impact on postoperative social functioning, energy/fatigue, and emotional well-being. Increased levels of PTSD were found in cardiac surgery patients following five years after the surgery.

摘要

背景

心脏手术是一项重大应激事件,会对患者的生活质量(QoL)产生显著负面影响,并可能导致长期的创伤后应激反应。本初步研究的目的是评估健康相关生活质量(HRQOL)动态变化的纵向变化及预测因素,并确定择期心脏手术后5年随访(T2)时与创伤后应激障碍(PTS)相关的因素以及与术前(T1)QoL的关联。

材料与方法

经地区生物伦理委员会批准后进行单中心前瞻性研究。纳入接受择期心脏手术的成年连续患者。在心脏手术前(T1)和术后5年(T2)使用医学结局研究36项简短健康调查(SF - 36)问卷测量HRQOL。使用国际创伤问卷评估创伤后应激。

结果

初步研究显示,在SF - 36的几个领域,5年随访时有显著的正向变化:身体功能(PF)、精力/疲劳(E/F)和社会功能(SF)。术后住院时间延长与SF(<0.01)、E/F(<0.05)和情感健康(<0.05)的变化相关。T2时患有创伤后应激障碍(PTSD)的患者比例为12.2%。创伤后应激症状与术后住院时间延长相关(<0.01)。

结论

HRQOL从基线到术后5年有所改善。术前HRQOL评分较低的患者术后5年HRQOL改善往往更显著。术后住院时间延长对术后社会功能、精力/疲劳和情感健康有负面影响。心脏手术患者术后5年发现PTSD水平升高。

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