无溶剂条件下聚苯乙烯负载双(乙氧基亚甲基)膦催化醛的 E-因子最小化氢膦酰化反应。
E-Factor minimized hydrophosphonylation of aldehydes catalyzed by polystyryl-BEMP under solvent-free conditions.
机构信息
Laboratory of Green Synthetic Organic Chemistry, CEMIN - Dipartimento di Chimica, Università di Perugia Via Elce di Sotto, 8, Perugia, Italia.
出版信息
Org Biomol Chem. 2013 Aug 14;11(30):5042-6. doi: 10.1039/c3ob40767e. Epub 2013 Jun 27.
An efficient protocol for the hydrophosphonylation of aromatic and aliphatic aldehydes catalyzed by PS-BEMP under solvent-free conditions (SolFC) has been reported. Addition reactions were performed by using equimolar amounts of reagents and the resulting α-hydroxyphosphonates were isolated with simple workup procedures. A large scale protocol for the preparation of a representative α-hydroxyphosphonate 3a has been also set up using a flow reactor.
已报道了在无溶剂条件下（SolFC）由 PS-BEMP 催化的芳香醛和脂肪醛的高效氢膦酰化的方法。通过使用等摩尔量的试剂进行加成反应，并用简单的后处理步骤分离得到的α-羟基膦酸酯。还使用流动反应器建立了用于制备代表性的α-羟基膦酸酯 3a 的大规模方案。
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