Fang Carolyn Y, Egleston Brian L, Ridge John A, Lango Miriam N, Bovbjerg Dana H, Studts Jamie L, Burtness Barbara A, Einarson Margret B, Klein-Szanto Andres J P
Cancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
Head Neck. 2014 Aug;36(8):1113-9. doi: 10.1002/hed.23421. Epub 2013 Oct 26.
Psychosocial functioning is associated with vascular endothelial growth factor (VEGF) in various patient populations. This study examined whether psychosocial functioning in patients with head and neck squamous cell carcinoma (HNSCC) is associated with tumor VEGF expression, a protein that stimulates angiogenesis and is associated with poor prognosis.
Forty-two newly diagnosed patients completed assessments of psychosocial functioning (ie, depressive symptoms, perceived stress, anxiety, social support) before surgery. Tumor samples were obtained for VEGF analysis and human papillomavirus (HPV)-typing.
Poorer psychosocial functioning was associated with greater VEGF expression controlling for disease stage (odds ratio [OR], 4.55; 95% confidence interval [CI], 1.72-12.0; p < .01). When examined by HPV status, the association between psychosocial functioning and VEGF remained significant among patients who were HPV negative (OR, 5.50; 95% CI, 1.68-17.3; p < .01), but not among patients who were HPV positive.
These findings inform our understanding of the biobehavioral pathways that may contribute to poor outcomes in non-HPV-associated HNSCCs.
在各类患者群体中，心理社会功能与血管内皮生长因子（VEGF）相关。本研究调查了头颈部鳞状细胞癌（HNSCC）患者的心理社会功能是否与肿瘤VEGF表达相关，VEGF是一种刺激血管生成且与预后不良相关的蛋白质。
42例新诊断患者在手术前完成了心理社会功能评估（即抑郁症状、感知压力、焦虑、社会支持）。获取肿瘤样本用于VEGF分析和人乳头瘤病毒（HPV）分型。
在控制疾病分期后，较差的心理社会功能与更高的VEGF表达相关（优势比[OR]，4.55；95%置信区间[CI]，1.72 - 12.0；p <.01）。按HPV状态进行分析时，心理社会功能与VEGF之间的关联在HPV阴性患者中仍然显著（OR，5.50；95% CI，1.68 - 17.3；p <.01），但在HPV阳性患者中不显著。
这些发现有助于我们理解可能导致非HPV相关HNSCC患者预后不良的生物行为途径。
